Antidepressant d

DRUGS
 Tricyclic antidepressents
uses
• Patients with psychomotor retardation
• Depression
• Sleep disturbances
• Poor apetite
• Weight lose
• Migraine
• Bipolar disease
• Chronic pain
• Attention deficit hyperactivity disorder
• Major depression
• Phobic and panic attacks
• Ocd obsessive compulsion disordrs
• Neuropathic pain
• Enureiss (imipramine)
• hypochondriosis
 SSRI USES + SNRI
• Major depression
• Ocd
• Bulimia( bhook zada lgna or zada khana)
• Anxiety
• Premenstrual dystrophic syndrome PMDD
• Post traumatic stress disorder
• Fibromyalgia
• Pain of diabetic neuropathy

• Bupropione used in smoking cessation

Ssri are more selective in action, minimal effects on NE
transport and adrenergic and cholinergic receptors
 Adverse effects of ssri (U.Q)
• Excess serotonin build up in git causes
• Nausea
• Gitupset
• Dirrhea
• Excess serotonin in spinal cord levels cause
• Sexual dysfunction libido dysfunction decreased

Delayed arousal
• Citalopram causes QT prolongation
• Excess serotonin syndrome
• Withdrawal syndrome anxiety dizziness palpitations tremor
• It also causes agitation
• Drug interactions  inhibit cytp450 function causing accumulation of TCA AND BETA BLOCKERS
 Toxixity of TCA
• Dry mouth
• Constipation
• Urinary retention above due to cholinergic bloavkade
• Tachycardi a
• Agitaion
• Sweating
• Insomai adue to sypathomimetic affects
• Orthostatic hypotension alpha receptor bloackade
• Weight gain in long term use
• In chronic use
• Convulsions
• coma
• Cardiac toxicity
• Circulatory collapse
• Respiratory depression
• Interactions include serotonin syndrome and hypertensive crisis with Moa INHIBITORS
TOXICITY OF MOAI

• HYPERTENSION
• HYPEHERMIA
• Convulsion
• Agitation
• Hypertensive crisis
• Serotonin syndrome
Very high yield in short ssri and snri first line benzodiazepines and tca , buspirone
2nd line