COMPARISON BETWEEN

SPIROMYCIN AND
TELITHROMYCIN

PHARMACOLOGY 3
SEMESTER 6
 TELITHROMYCIN IS THE KETOLIDES AND THE SPIROMYCIN IS MACROLIDES.
 THERE IS A PRESENCE OF A 3-KETO FUNCTION IN PLACE OF THE L-CLADINOSE MOEITY.
 THEY BOTH MACROLIDES AND KETOLIDES THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
 BY BINDING TO THE 50S RIBOSOMAL SUBUNIT AND BLOCKING TRANSPEPTIDATION.

SPIRAMYCIN TELITHROMYCIN
EFFECTS

 TELITHROMYCIN IS USED FOR THE TREATMENT OF PNEUMOCOCCAL INFECTION AND

LOWER RESPIRATORY TRACT INFECTIONS[PNEUMONIA].
 SPIRAMYCIN IS USED TO TREAT VARIOUS INFECTIONS AGAINST GRAM POSITIVE COCCI
AND RODS.
 SPIRAMYCIN ASSOCIATED CONDITIONS: BACTERIAL INFECTION.
 TELITHROMYCIN ASSOCIATED CONDITIONS: MILD AND MODERATED COMMUNITY
ACQUIRED PNEUMONIA.
 OTHER CONTRAINDICATIONS

 SPIRAMYCIN HAS LOW LEVEL OF ABSORPTION OF 30-39%[ORAL BIOAVAILABILITY] THAN

TELITHROMYCIN OF 57%[ORAL ADMINISTRATION].
 PROTEIN BINDING IS 60-70% OF TELITHROMYCIN WHEREAS LOW PROTEIN BINDING IS
FOUND IN SPIRAMYCIN OF 10-25%.
 TOXICITY: TELITHROMYCIN DIARRHEA, NAUSEA, VOMITING, FLATULENCE AND
DYSPEPSIA.
SPIRAMYCINCARDIAC TOXICITY SPECIFICALLY QT PROLONGATION,
CHOLESTATIC HEPATITIS, ETC.
BACKGROUND

 TELITHROMYCIN IS A SEMISYNTHETIC ERYTHROMYCIN DERIVATIVE BELONGS TO A NEW

CHEMICAL CLASS OF ANTIBIOTICS CALLED KETOLIDES.
 SPIRAMYCIN IS A PRIMARILY BACTERIOSTATIC MACROLIDE ANTIMICROBIAL AGENT WITH
ACTIVITY AGAINST GRAM-POSITIVE COCCI AND RODS, GRAM-NEGATIVE COCCI AND ALSO
LEGIONELLAE, MYCOPLASMAS, CHLAMYDIAE, SOME TYPES OF SPIROCHETES,
TOXOPLASMA GONDII AND CRYPTOSPORIDIUM. SPIRAMYCIN IS A 16-MEMBERED RING
MACROLIDE.
 TELITHROMYCIN IS BACTERICIDAL WHEREAS SPIRAMYCIN IS BACTERIOSTATIC.
THANK PH016 DWIJPATEL
PH044 SATYAM KOTAK

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