Lynda Coates – Jun 2015

cobas® 8100 automated workflow series, version 2

Creating a Layout: Types of Layouts, rules and Limitations,
When do you need what…
cobas® 8100 automated workflow series v2
Types of Layouts
1. Group Layouts - Each group consists of various Sub-layouts

Guidelines:
 1-6 Instrument connections with up to 8 TLJs
 Connected and Basic L-connections, and 2 nd Output Station at the end of the layout

 What differentiates Layout Groups?

a. Number of Connected Instruments
b. Number of TLJs
c. Position of cobas® 8100 & Instruments, based on the junction to which they are connected

 Does not trigger for new Layout Group

a. Change in direction of TLJ
b. Change in direction of cobas® 8100 & Instruments connection on the junctions
Layout Release Process for cobas® 8100 aws v2
Concept of Layout Group with Sub-Layouts
Layout Group analyzer
600 JCT 600 JCT

cobas 8100 analyzer

JCT

1800
3000 JCT 1800 JCT 1800 JCT
JCT

600 JCT

JCT
analyzer

analyzer

analyzer
600

cobas 8100

1800
analyzer

JCT
cobas 8100

analyzer
analyzer

1800
900
3000
JCT
analyzer

JCT

JCT
cobas 8100
1800
Sub-Layouts
analyzer
analyzer

JCT
analyzer

1800
JCT
3000 JCT 1800 JCT 600 JCT
JCT

600
analyzer

1800
600

analyzer
analyzer

analyzer
600

JCT
600 JCT
600 JCT
analyzer analyzer
cobas 8100

cobas 8100

JCT
600 JCT

Note: The following layouts are not the same with the above layout
1500 JCT

JCT
cobas 8100
600

analyzer
JCT 600
JCT

3000 JCT 1800 JCT

JCT
1800 JCT 1800 JCT

1800
analyzer

analyzer

analyzer
600
analyzer

analyzer
analyzer

analyzer
cobas 8100

JCT 600

JCT
600
600 JCT

cobas 8100 analyzer

Page 3, © 2009 Roche

cobas® 8100 aws v2
Eligible for Group Layouts
Simple case with L connectors
Simple case – up to 6 connections and 8 TLJs (SLR or SLL with up to 6 connections and 8 TLJs)
C
OPS IPS AQS R
OPS IPB

AA
1

AQS

AA
AA AA AA

R
C
1
AA

AA
2nd Output Station as an end station
C C C
OPS
OPS IPS AQS R L R

C
R
1
2

AA
1 1 2

AQS
AA AA
OPS IPS

AA
• Combinations of these features are possible

Note: Aliquoting station is always optional

Page 4, © 2009 Roche

cobas® 8100 automated workflow series v2
Types of Layouts
2. Specific Layouts - Each group consists of various Sub-layouts

Guidelines:
 7-8 Instrument connections or > 8 TLJs
 Complex Split of stations, including a 2nd Output Station that is not an end element
cobas® 8100 automated workflow series
Components Overview
OPS - 1 up to 2 AQS - Optional
Output station Input station Aliquot station

1 2 3 4 5 6 7 8 9

1 Restopper flex-cap/srew cap – up to 2 6 Sample check module – up to 1

2 Add-on/output buffer – up to 3 7 Destopper - 1
3 Output buffer/sorter – 1 to 2 8 Barcode labeler/tube feeder –up to 2
4 Input buffer – 1 (in development up to 2) 9 Aliquot module – up to 1
5 Automatic centrifuge unit – up to 3

Page 6, © 2009 Roche

cobas® 8100 aws v2 To build additional station
versions: choose the correct base
configurations station, with the correct number
of AOBs and add the additional
Cobas 8100 v2 - stations OBS and/or RSF modules to the
 Default order of stations is always mandatory (OPS – IPS - AQS) correct end

Left-side cover for OPS:

Page 7, © 2009 Roche

 To build additional station
cobas® 8100 aws v2 versions: choose the correct base
configurations – cobas 8100 v2 - stations station, with the correct number
of ACUs (with or without SCM)
Input Station (IPS): and add the additional modules
to the correct end
 Default order of stations is always mandatory (OPS – IPS - AQS)

All IPS options are also

available with the SCM.
Example:

Page 8, © 2009 Roche

cobas® 8100 aws v2
configurations – cobas 8100 v2 - stations
Aliquot Station (AQS):
 Default order of stations is always mandatory (OPS – IPS - AQS)

Page 9, © 2009 Roche

cobas® 8100 aws v2
2nd Output Station as an End Element
• Eligible for Group Layouts
• Important: The 2nd Output Station needs to end with CRO and nothing connected beyond

Example A: Example B:

Example C:
Note: Example C may require a special cover
for the direct connection to the side of the
Junction.

Page 10, © 2009 Roche

cobas® 8100 automated workflow series v2
Layout Components Overview
Cobas 8100 v2 – connection modules

Page 11, © 2009 Roche

cobas® 8100 aws v2
Simple L-Connections: SLR & SLL

Used to split the cobas® 8100 stations into a basic L-formation

 No pitch change or extra power are required
 Note: Default order of stations is mandatory (as for direct linear connected configurations)

Example SLR: SLL: Simple L-Connection Left

SLR: Simple L-Connection Right

Example SLL:

Page 12, © 2009 Roche

cobas® 8100 aws v2
Layout Components
Right and Left Connectors
 Changes the pitch, so the lines are symmetrical and close the loop for single holders in the conveyor area
Why would you need to close the loop?

Right Connectors: CRW & CRO

 Connector for the lines and junctions on the right side of the cobas 8100 ® stations
CRW: Supplies power forward
 How much can it power?
Up to 6 RFM’s & 11 Line/Junctions
CRO: What is the difference from the CRW?
 When would you use this component?
On the right side of a 2nd Output Station
Left Connectors: CLW & CLO
 Connector for the lines and junctions on the left side of the cobas 8100® stations
CLW: Supplies power forward
 When would you use this component?
Powers the connected (Output or Aliquot) station
CLO:
 When would you use this component?
On the left side of a complex split Input station

Page 13, © 2009 Roche

 CRW: Supplies power to
the layout, closes the
loop and changes the
pitch
 Any combination of version 2 layout components that is within the guidelines is allowed between the stations

CLW: Provides power to

the Aliquot Station,
closes the loop, and
changes the pitch
CRW: Supplies power to
the lines, closes the loop
and changes the pitch
Page 14, © 2009 Roche
 Instruments can be connected where there are junctions
 Default order of stations is always mandatory

CLO: Closes the loop

Complex split of stations

and changes the pitch

cobas® 8100 aws v2

CRW: Supplies power to

the lines, closes the loop
and changes the pitch
Example # 1:
CLW: Provides power to
the Output Station, and
closes the loop
cobas® 8100 aws v2
Complex split of stations

Example # 2
 Instruments can be connected where there are junctions

Page 15, © 2009 Roche

cobas® 8100 aws v2
Transport Lines and Junctions (TLJ)

Upstream Downstream

Line Junction
(L=300 - 3000) (500)

Available components
 TLJ
300/600/900/1200/1500/1800/2100/2400/2700/300
0 (Ordered as a line with a junction connected)

Junction
 Length = 500 mm
 Analyzers are directly connected to a junction

Page 16, © 2009 Roche

cobas® 8100 aws v2
Lines and Junctions with Power Extension Unit (PXT)

PXT = Power Extension Unit

Possible TLJ Lengths you can add a PXT unit to:

 TLJ 1800/2100/2400/2700/3000

Information:
 Required when greater than 6 connections and/or
11 TLJs
 Can power up to 6 connections and/or 11 TLJs

Page 17, © 2009 Roche

cobas® 8100 aws v2 Reformatters (RFM)
Layout Components  are directly connected to a Junction;
o side or end

Unidirectional RFM: URF Bi-directional RFM: BRF Sysmex Bi-directional RFM: RFX
 Uni-directional connection  Bi-directional connection  Bi-directional connection
 Connects cobas 6000, Stago  Connects cobas 8000, p 501/701  connects Sysmex XN (with a right to
right workflow)

Page 18, © 2009 Roche

cobas® 8100 aws v2
Connection Requirements: RFX - Bi-directional

XN Connection requirements to cobas 8100:

 Right side connection
 right to right rack flow from the front
lines
 Configurations including the following
modules are not approved by Sysmex:
TS 10, 500, 2000, or any 3rd party
systems (ex. Tosoh and Interrliner)

Responsibility of Sysmex
 Sysmex XN workflows and workflow
planning
 Connectability of the different XN
configuration options

Page 19, © 2009 Roche

 cobas® 8100 aws v2
Connection Requirements: RFX - Bi-directional

Schematic XN-9000 layout for connection to Roche RFX

Page 20, © 2009 Roche

cobas® 8100 aws v2
Possible XN-9000 configurations with the Roche RFX Interface
• Following individual Sysmex components can be used to build up the
XN-9000 configuration, connectable to the CCM:
• XN-9000 without tube sorting functionality (Compact Integration)

Page 21, © 2009 Roche

cobas® 8100 aws v2
RFX - Bi-directional: Connection Examples

Page 22, © 2009 Roche

 cobas® 8100 aws v2 The following stencils are only to be used only with a disclaimer: as they are in development

Layout Components - Draft

UCU:
 is directly connected to a Junction;
Bi-directional Connection: o side or end
 Liaison Connection Module (LCM)
 Phadia Connection Module

BLM connection using the UCU: (currently

under review)
 Connected in place of an analyzer
 Either between a complex Split of station or
on the right side of the cobas 8100
Example:

Page 23, © 2009 Roche

cobas® 8100 automated workflow series v2
Layout Components Overview
Cobas 8100 v2 – connection modules continued

The following stencils are only to be used only with a disclaimer: as they are in development

Uni-directional connection to u 6500

Page 24, © 2009 Roche

cobas® 8100 automated workflow series v2
Layout Components Overview
Cobas 8100 v2 – connection modules continued

The following stencils are only to be used only with a disclaimer: only in planning stage
(connections not officially available)

cobas 6800/8800 are

still pending NAT
carryover testing

Page 25, © 2009 Roche

cobas® 8100 aws v2
Bulk Loader connections – with dedicated BLM Interface
Available at Launch + 21-24 mths - Timelines under review
Examples of dedicated BLM Interfaces:
C C C C
OPS IPS ALQ OPS IPS ALQ OPS
BLM R BLM R L R
(1) (1) (1) (1) (1) (1) (2)
1 1 1 2

AA AA
AA AA

C C C C
IPS ALQ OPS
BLM L R L R
(1) (1) (1)
2 1 1 2

AA AA

• The dedicated BLM interface is at the left of the OPS

• Depending on workflows some throughput limitations might occur
• Eligible for Group Layouts once group layouts start
Note: Aliquoting station is always optional

Page 26, © 2009 Roche

 cobas® 8100 aws v2
Layout Design – Service Space Requirements

Minimum distance
between a wall and a TLJ
needs to be 70 centimeters
(also visible in the latest
Visio stencils)

Minimum distance in the

back of the c8100 needs
to be 80 centimeters (also
visible in the latest Visio Minimum distance in
stencils) the back of a BRF
needs to be 70*
centimeters (also
visible in the latest
Visio stencils)

* This distance is also required for some operator actions

Page 27, © 2009 Roche

cobas® 8100 aws v2
Layout Design Limitation 1
Example 1:

Length of the 2nd TLJ should be

TLJ1200 or longer when the 2nd
TLJ is connected to the straight-
end of the 1st TLJ with an RFM
is connected on the left-side.
 This is relevant anywhere this
occurs in a layout

PCBs in the 2nd TLJ cannot be

accessed if less than
TLJ1200.
TLJ 1 TLJ 2: TLJ 1200 or
longer
Impact if PCBs cannot be accessed: If the TLJ requires service; the entire system
will need to be taken off-line and the TLJ de-installed, repaired and the re-installed.

Page 28, © 2009 Roche

cobas® 8100 aws v2
Layout Design Limitation 1: Example 2

TLJ 2: needs to be
TLJ 1200 or longer.
Not the TLJ 600 seen TLJ 1, of RFM
here connection

Page 29, © 2009 Roche

cobas® 8100 aws v2
Layout Design Limitation 1: Example 3

TLJ 2: needs to be
TLJ 1200 or longer.

TLJ 1, of RFM
connection

Page 30, © 2009 Roche

 cobas® 8100 aws v2
Layout Design Limitation 2
Example 1:

Length of the 2nd TLJ should be

TLJ1500 or longer when the 2nd
RFM is connected to the right-side
of the 2nd TLJ and RFM 1 is
connected to the left-side of TLJ 1.

 This is relevant anywhere this

occurs in a layout
RFM 1

Electrical components in the

transport line cannot be
accessed if less than TLJ1500.

TLJ 1500 or
Impact if electrical components cannot be accessed: If the TLJ requires RFM 2
greater
service; the entire system will need to be taken off-line and the TLJ de-installed,
repaired and the re-installed.

Page 31, © 2009 Roche

cobas® 8100 aws v2
Layout Design Limitations
Why may a TLJ not be covered by a Reformatter or other module?
There is an access needed to the electronics part which is only accessible from one side.

The door is accessible only from …and is opened using a hinge.

one side …

Page 32, © 2009 Roche

cobas® 8100 aws v2
Layout Design: Example 1

Page 33, © 2009 Roche

cobas® 8100 aws v2
Layout Design: Example 2

Page 34, © 2009 Roche

cobas® 8100 aws v2
SAB_PIF Tool kit

• Contains 3 documents:

• Never edit these documents or they may not work properly

• Instructions can be found in the first tab
• This document is used for:
• Project submission to the BA
• PIF submission to HHT for quotations (first 5 tabs after the Instructions)
• Country project planning
• Creating order lists

Available on the cobas 8100 page of WF & IT Intranet site

Page 35, © 2009 Roche
Thank you for your attention
Roche Diagnostics Ltd.
CH-6343 Rotkreuz
Switzerland

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it shall neither be copied in any manner, nor used for manufacturing, nor
communicated to third parties.