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    Divya
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    1. There are several drugs used to treat mild to moderate Alzheimer's disease including reversible anti-cholinesterases like tacrine and newer ones like donepezil, rivastigmine, and galantamine. These drugs improve memory, cognition, and well-being by facilitating the release of acetylcholine. Common side effects include nausea and diarrhea. 2. Other treatment options include acetyl-L-carnitine which is a structural analogue of acetylcholine, and memantine which is a non-competitive antagonist of NMDA receptors. 3. Some research has also shown beneficial effects from drugs like rosiglitazone, statins, ibuprofen, as well as

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    1. There are several drugs used to treat mild to moderate Alzheimer's disease including reversible anti-cholinesterases like tacrine and newer ones like donepezil, rivastigmine, and galantamine. These drugs improve memory, cognition, and well-being by facilitating the release of acetylcholine. Common side effects include nausea and diarrhea. 2. Other treatment options include acetyl-L-carnitine which is a structural analogue of acetylcholine, and memantine which is a non-competitive antagonist of NMDA receptors. 3. Some research has also shown beneficial effects from drugs like rosiglitazone, statins, ibuprofen, as well as

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    5 views20 pages

    Alz

    Uploaded by

    Divya
    1. There are several drugs used to treat mild to moderate Alzheimer's disease including reversible anti-cholinesterases like tacrine and newer ones like donepezil, rivastigmine, and galantamine. These drugs improve memory, cognition, and well-being by facilitating the release of acetylcholine. Common side effects include nausea and diarrhea. 2. Other treatment options include acetyl-L-carnitine which is a structural analogue of acetylcholine, and memantine which is a non-competitive antagonist of NMDA receptors. 3. Some research has also shown beneficial effects from drugs like rosiglitazone, statins, ibuprofen, as well as

    Copyright:

    © All Rights Reserved
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    of 20

    Treatment Drugs

    1. Reversible anti-cholinesterases (Mild and Moderate forms of AD


    Ex. Tacrine
    -Orally active
    -provides improvement in memory cognition and general well being
    -It also facililitates the release of Ach fro nerve endings
    Adverse effects
    hepatotoxicity,- use was restricted

    2. Newer Reversible antcholinesterase inhibitors


    Ex:Donepezil, (5mg once /day)
    rivastigmine, (1.5mg orally BD)
    galantamine (4mg orally BD)

    Adverse effects
    Peripheral cholinergic side effects (Diarrhoea, nausea and vomiting)
    3. Structural analouges of Ach
    Ex: Acetyl –L-carnitine
    4. Non –competitive antagonist of NMDA receptors
    Ex Mimantine

     Some research studies showed that Rosiglitazone, statins, Ibuprofen shows beneficial effect in
     Vit A, C antioxidants, zinc, selenium biflavanoids significantly reduces the progression of AD.
    Addiction
    Intense craving to procure the drug by any means
    Development of tolerance(Need more dos go get the same rewarding experience)
    Lifethreatening withdrawl effects

    Habituation
    No intense craving for seeking
    No development of tolerance
    No distressful withdrawl effect
    1. Short term substitution of the abused drugs
    2. Aversion therapy
    3. Use of proper antagonists to prevent relapse

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