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Jagadguru Sri Shivarathreeshwara University

JSS College of Pharmacy, Mysuru -570 015
M. Pharm First Sessional Examination February,2017
. Note: Your answer should be specific to the questions asked.
Draw neat labeled diagrams wherever necessory.

Time:l.S hrs Subject: Principles of Toxicology Max. Marks : 30

Semester: II Program: Pharmacology

I. LONG ANSWERS (Answer any ONE questions) l0 x I : l0 Marks

I . Define GLP. Brief about history, scope and principles of OECD on GLP

2. Explain the principle and method involved in skin sensitization test as per OECD TG 406

II. SHORT ANSWERS (Answer any FOUR questions) 5 x 4 = 20 Marks

3. Explain the acute dermal toxicity procedure in rats as per OECD TG 402

4. Give note on dose conversion formula based on metabolic factor.

5. Explain how you will prepare 200 mg/kg, p.o dose of a drug X for rats and mice, clear

information on amount of drug weighing and dose volume. Most important is minimum

utilisation of drug and vehicle.

6. Explain the recommended conditions on temperature, humidity, light, sound, photoperiod

to be maintained in a small animal facility.

7. Explain OECD TG 423 with starting dose 2000mg/kg

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 JSS Academy of Higher Education and Research
JSS College of Pharmacy, Mysuru -570 015
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M. Pharm First Sessional Examination Feb' 2018
Note: Your ansv'er should be specilic to the queslions asked.
[)rov, neal labeled diagrams v'herever necessary
Subject:Pharmacologicaland'Ioxicological Max,Marks:30
Time:1.5 h Screening Methods- II
Semester: II Program: PharmacologY
10 x 1=10 Marks
I. LONG ANSWERS (Answer any ONE questions)
1. Principle ar.rd method of28 repeated oral dose toxicity study

,Detir.re-general.mechanistic,regulatoryanddescriptivetoxicity'Writetheprinciplesof
OECD
(Answer any I'OIJR questions) 5x 4=20 Marks
II. SHORT ANSWERS

3. Principle of AMES test

4. Write the responsibilities of Test Facility Management

5. Discussthemethods-Invivomicronucleiassays

6. Principles of in vivo chromosomal aberration assay

7. Write ttre responsibilities of study director

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Jagadguru Sri Shivarath reeshwara University

.ISS College of Pharmacy, Mysuru -570 015
M. Pharm Second Sessional Examination April,2017
Note: Your onsuzr should be speci/ic to the queslions ctsketl.
Druu, ncut lubelcd diagrunt.t v'herevcr ncce.t.tory
Time:l.S h Subject: Principles of Toxicolog- Max. Marks:30

Semester: II Program: Pharmacology

1., LONG ANSWERS (Ansrver any ONE questions) l0 x l=10 Marks
I. Principle and method ofeye irritation test
2. Discuss the nrethods - In vitro and In vivo micronuclei assays
II. SIIORT ANSWERS (Answer any FOUR questions) 51 4=20 M:rrks

J. Dellnition and importance of IND

4. Principle of AMES test

5. Deflne test item characterization

6. t'r-ote on imporlance of CVS screening in salety phan.r.racology

7- Define chromosomal aberration assav