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  • Modularea Timpurie A Răspunsului Imun La COVID-19 Rolul Inhibiției IL-1

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    Barbu Vasile
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    The document discusses COVID-19 stages and pathogenesis. It reviews approved therapies for moderate to severe COVID-19 such as corticosteroids and immunotherapies targeting hyperinflammation. The document also discusses the SAVE-MORE clinical trial investigating the use of Anakinra for COVID-19, including its study design, patient population, stratification approach, and primary endpoints focused on clinical progression and respiratory failure. Biomarkers for predicting response to therapies and early prognostication are also reviewed.

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    Modularea timpurie a răspunsului imun la COVID-19 Rolul inhibiției IL-1.pptx

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    The document discusses COVID-19 stages and pathogenesis. It reviews approved therapies for moderate to severe COVID-19 such as corticosteroids and immunotherapies targeting hyperinflammation. The document also discusses the SAVE-MORE clinical trial investigating the use of Anakinra for COVID-19, including its study design, patient population, stratification approach, and primary endpoints focused on clinical progression and respiratory failure. Biomarkers for predicting response to therapies and early prognostication are also reviewed.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    6 views54 pages

    Modularea Timpurie A Răspunsului Imun La COVID-19 Rolul Inhibiției IL-1

    Uploaded by

    Barbu Vasile
    The document discusses COVID-19 stages and pathogenesis. It reviews approved therapies for moderate to severe COVID-19 such as corticosteroids and immunotherapies targeting hyperinflammation. The document also discusses the SAVE-MORE clinical trial investigating the use of Anakinra for COVID-19, including its study design, patient population, stratification approach, and primary endpoints focused on clinical progression and respiratory failure. Biomarkers for predicting response to therapies and early prognostication are also reviewed.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 54

    Introduction

    COVID-19 Stages
    COVID-19 Stages
    COVID-19 Stages
    COVID-19 Stages
    COVID-19 Stages
    COVID-19 Stages
    COVID-19 Underlying Mechanism of
    Pathogenesis
    Local Pathophysiology of COVID-19
    Approved Therapies for Moderate to Severe
    COVID-19
    Approved Therapies for Moderate to Severe
    COVID-19
    Approved Therapies for Moderate to Severe
    COVID-19
    Standard-of-Care Treatment
    WHO Guidelines
    Standard-of-Care Treatment
    WHO Guidelines
    Meta-Analysis
    Use of Steroids in COVID-19 Treatment
    Meta-Analysis
    Use of Steroids in COVID-19 Treatment
    Meta-Analysis
    Use of Steroids in COVID-19 Treatment
    Meta-Analysis
    Use of Steroids in COVID-19 Treatment
    Meta-Analysis
    Use of Steroids in COVID-19 Treatment
    Corticosteroids vs Immunotherapy
    Therapies Targeting Hyperinflammation
    Therapies Targeting Hyperinflammation
    Therapies Targeting Hyperinflammation
    Therapies Targeting Hyperinflammation
    Therapies Targeting Hyperinflammation
    Therapies Targeting Hyperinflammation
    Lessons Learned From IL-6 Inhibitor Trials
    Lessons Learned From IL-6 Inhibitor Trials
    Lessons Learned From IL-6 Inhibitor Trials
    Lessons Learned From IL-6 Inhibitor Trials
    IL-1 and DAMPs in COVID-19
    IL-1 and DAMPs in COVID-19
    IL-1 and DAMPs in COVID-19
    Clinical Trials Investigating Anakinra for
    COVID-19
    SAVE-MORE Study
    Patient Population
    SAVE-MORE Study
    Patient Population
    SAVE-MORE RCT
    Study Design
    SAVE-MORE Study
    Patient Stratification
    SAVE-MORE Primary Endpoint
    11-Point WHO Clinical Progression Ordinal Scale by Day 28
    SAVE-MORE Primary Endpoint
    11-Point WHO Clinical Progression Ordinal Scale by Day 28
    SAVE-MORE Trial
    Time to Respiratory Failure
    Importance of Early Risk Stratification in
    COVID-19
    Importance of Early Risk Stratification in
    COVID-19
    Biomarkers for Sarilumab-Responsive
    COVID-19
    Validation of suPAR for Early
    Prognostication
    Validation of suPAR for Early
    Prognostication
    Validation of suPAR for Early
    Prognostication
    Validation of suPAR for Early
    Prognostication
    Concluding Remarks
    Abbreviations
    Abbreviations (cont)

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