DEVELOPMENT OF CONNECTIVE TISSUE

Mesenchyme Loose Connective Tissue

Fibers

Fibroblasts
Mesenchymal
Cells
Cell Lineage from Mesenchymal Cells
 TYPES OF CONNECTIVE TISSUE
Loose Connective Dense Irregular Dense Regular
Tissue Connective Tissue Connective Tissue

(e.i. mesentery, omentum) (e.i. dermis of skin) (e.i. tendons, ligaments,

cornea)
DENSE IRREGULAR CONNECTIVE TISSUE
(DERMIS OF SKIN)
 DENSE REGULAR CONNECTIVE TISSUE

Tendon (longitudinal Section) Tendon (tranverse Section)

ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL

Internal
elastic
lamina
 CONNECTIVE TISSUE FIBERS
Collagenous Fibers Reticular Fibers Elastic Fibers
(bundles) (networks) (anastomosing bundles)
RETICULAR CONNECTIVE TISSUE

reticular fibers
(argyrophilic)
 Fiber COLLAGEN
Fibril

Microfibril

FIBER Periodic Bands

BUNDLE

Tropocollagen

alpha 1 peptide
alpha 2 peptide

TEM of Collagen Fibers SEM of Collagen Fibers

SCANNING EM OF COLLAGEN FIBER BUNDLES
 TEM of Fibroblast and Collagen Bundles
FIBROBLAST

collagen fiber
RER bundles
procollagen

tropocollagen Collagen Types

I - skin, bone, tendon cornea (most common type)
ground II- cartilage, embryonic cornea
substance III- reticular fibers, loose c.t., blood vessel walls, dermis
(mucopolysaccharide) IV- basal lamina of epithelium
(no fibers, mat of randomly-oriented molecules)
TEM OF FIBROBLAST WITH COLLAGEN BUNDLES
 FIXED CONNECTIVE TISSUE CELL TYPES

Fibroblast Adipocytes
(fiber producing cell) (fat storage)

Fibrocyte Fixed Macrophage

(histiocyte)
(mesenchymal- pluropotent)
Fixed Connective Tissue Cells
Macrophage (light micrograph)

Adipocytes

fibroblast

TEM of Macrophage
 MONONUCLEAR PHAGOCYTIC SYSTEM
(reticuloendothelial system) Giant Cell
Monocyte

Mononuclear coalescence
wandering
cell

Microglial Sinusoidal
Macrophages Osteoclasts Kupffer Cells Cells Endothelia
spleen liver
bone liver central
lymph nodes sinusoids nervous spleen
resorption marrow
bone marrow system
connective tissue
lung ( all characterized by phagocytic activity)
serous cavities
 LYMPHOCYTES AND PLASMA CELLS
(Agents of the immune response)
(produce
Lymphocytes Plasma Cells immunoglobulins
-antibodies)
differentiation stimulated by
immune activation
 EOSINOPHILES MAST CELLS

Secretion Products:
actively phagocytic 1. Slow-reaction substance of anaphalaxis
destroy immune complexes 2. Heparin- anticoagulant
(antigen-antibody) 3. Histamine- stimulates inflammation
4. Serotonin- vasoconstrictor
5. Eosinophil Chemotactic Factor
 Connective Tissue Cells

Plasma Cell

Lymphocyte

Macrophage
TRANSMISSION EM OF AN EOSINOPHILE
TRANSMISSION EM OF A MAST CELL