RENAL CASE 3

A2 GROUP 10
CLINICAL PATHOLOGY
BUN, CREATININE & CREATININE
CLEARANCE
 Creatine & Creatinine

Creatine  main storage compound of high-energy

phosphate needed for the muscle metabolism.

Synthesized mainly in the liver from arginine, glycine,

and methionine. Gender Serum Total
creatinine(N) creatinine
Under physiologic conditions, creatine loses water excretion

spontaneously, to form its cyclic amide, creatinine. Male 0.6 to 1.2 1.0
mg/dL to 2.0 g/24 h

Creatinine and creatine are freely filtered by the Female 0.5 to 1.0 0.6 to
mg/dL 1.5g/24 h
glomeruli , creatine is mostly reabsorbed where
creatinine is not. Children <12 0.3 to 1.0
y/o mg/dL

Elevated serum creatinine is associated with a decrease

in the glomerular filtration rate (GFR).
 Blood Urea Nitrogen

Urea is the major excretory product of protein catabolism.

Over 90% of urea is excreted through the kidney, where it is

readily filtered from the plasma by the glomerulus

Urea is one of the most popular laboratory tests for assessing Parameter Reference
renal function. BUN 8 to 20 mg/dL

An increased level of urea in the blood is called azotemia.

Excretion 17 -20 g /24 h.
To enhance the clinical interpretation, it is recommended that
both serum urea and creatinine measurements be performed
followed by a calculation of the B/C ratio.
 Creatinine Clearance
It determine, how much plasma is cleared off
creatinine per minute.

It is also used to assess GFR.