Professional Documents
Culture Documents
Khandelwal, DO
Kevin Biese, MD, MAT
Ellen Roberts, PhD, MPH
Jan Busby-Whitehead, MD
2
The Case of Mrs. TW
Mrs. TW is a 79yo female with
history of HTN, MCI, and
urge incontinence, who
was admitted for a
pneumonia. She is stable
on admission and sent to
the floor with a foley
catheter in-place.
3
BACKGROUND
• Cascade iatrogenesis is a series of adverse
events triggered by an initial medical or
nursing intervention initiating a cascade of
decline.
» Occurs most frequently among the oldest,
most functionally impaired patients and those
with a higher severity of illness upon
admission.
4
BACKGROUND
5
Iatrogenesis in Older Patients
• Age-related factors that predispose the older
patient to iatrogenesis
• More co-morbid, chronic medical conditions
that require more diagnostic procedures and
medications
• Increased severity of illness and complexity
of care
• Longer length of stay
6
Elderly Are the Most Likely to
Suffer…
Adverse Drug Events
Delirium
Nosocomial Infections
Falls
Procedural/Surgical Complications
7
Adverse Drug Events
• Most common type of iatrogenic injury
• Predictors
» > 4 meds
» LOS > 14 days
» > 4 active medical problems
• # of drugs is the strongest predictor;
potential for interaction: 2 drugs 6%, 5
drugs 50%, ≥ 8 drugs nearly 100%
• 70-80% of ADEs in the elderly are dose
related
• 30-50% preventable!
Carbonin P et al. 1991
8
Adverse Drug Events
9
Adverse Drug Events
Common Drugs Common Effects
Sleepers Infections
Narcotics Gastrointestinal
Digoxin Falls
Anti-hypertensives
10
The Case of Mrs. TW
Twenty four hours after
admission, nursing staff call
to report that Mrs. TW is
“yelling out and trying to catch
the butterfly in the hall.” With
further report from the nurse,
the patient has a fever.
11
Delirium
• Delirium is one of the most common iatrogenic
complications in hospitalized elders affecting 50%
or more post-operative hip fracture and thoracic
surgery patients over age 65.
Elie 1998, Ely 2004, Inouye 1996, Inouye 2006, Pompei 1994
12
Risk Factors for Delirium
• Age ≥ 70 years
• Existing cognitive impairment
• Functional impairment
• Alcohol abuse
• Abnormal preoperative level of sodium,
potassium or glucose
• Preoperative psychotropic drug use
• Depression
• Increased comorbidity
• Living in a long-term care facility
• Visual or hearing impairment
13
Preventing Delirium
• At least 3 clinical trials suggest that minimizing risk factors
in hospital can reduce delirium:
14
Preventing Delirium
» Geriatrics consultation reduced delirium in the
acute hospital management of hip-fracture
patients (Marcantonio, E.R., 2001)
15
Treatment for Delirium
• Almost no drug studies of established delirium
• Most experts would use traditional or atypical
antipsychotic agents in low dose for agitated
delirium treatment
» What about anticholinesterase inhibitors?
(Donepezil use in the prevention and treatment of post-
surgical delirium did not prevent delirium.)
16
Nosocomial Infections
17
Urinary Catheters
• 25% of hospitalized pts have indwelling catheter
• Associated with LOS, inpatient mortality
• Inappropriate for over 50% of inpatient days
• Uncomfortable / Restrictive
18
Urinary Catheters
• Catheter-associated urinary tract infections
(CAUTIs) represent the most common
nosocomial infection, accounting for 40% of
all hospital-acquired infections.
19
Indications for Urinary
Catheterization
• Output monitoring of unstable patients
• Complete urinary retention
• Urinary incontinence in patients with wounds
or skin defects
• Urinary incontinence in general is not an
indication for catheterization, but it may be
considered for patient comfort at the request
of the patient or family
• Terminally ill patients
• Perioperative use
20
If Not a Foley…What Instead?
• Prevention and Treatment –
» Plan may include reviewing medications
(opiates, anti-cholingerics, diuretics, alpha-
adrenergic agonists, calcium-channel blockers
are offenders)
» Treat UTI (contributes to urge incontinence)
» Treat constipation
» Seek any reversible causes of delirium
» Regular toileting schedule
21
The Case of Mrs. TW
Wrist restraints were placed
on Mrs. TW to help
maintain her delirium
tonight. Three hours later,
nursing staff calls you to
report a fall for Mrs. TW.
You order a stat hip x-ray
and an acute fracture is
found.
22
Why are Restraints Used?
• Prevent falls
• Prevent injuries
• Prevent treatment disruption
• Manage confusion
23
AGS Positional Statement:
Restraints are acceptable to use:
25
If Not a Restraint…What
Instead?
• Non-pharmacological
» Cognitive
» ◦ Orientation (calendar, caregiver names)
» ◦ Activities (cognitively stimulating)
» Sleep
• ◦ Regular routine
• ◦ Sleep aids (relaxing music, massage)
• ◦Environmental (eliminate noise, night-time meds)
» Mobility (range of motion, limit IV’s, etc)
» Visual Aids (glasses, large dial phones)
» Hearing Aids (check ear wax)
» Volume repletion for dehydration
Inouye 1999
26
Pharmacologic Treatment
• No medication is FDA approved for the
treatment of delirium
Slide from Rachelle Bernacki MD Bree Johnston MD Division of Geriatrics University of California San
Francisco and San Francisco, VA Medical Center
27
Reduce Falls
• Reduce restraint use / lower bed rails
• Prevent delirium
• Sensor alarms
• Non-slip shoes
• Remove obstacles
28
Falls
• Falls frequently occur in hospitals, and the
patients most likely to fall are older patients
29
Fall Risks
• Visual impairment
• Hypotension / anti-hypertensives
• Anticholinergics / sedative-hypnotics
• Obstacles / slick surfaces
• Elevated bed height
• Confinement ….restraints!
30
Fall Prevention Strategies
• Unfortunately, there are no specific
recommendations to reduce the risk for falls in
the acute care setting.
31
Fall Prevention Strategies
• Frequent and varied staff education and re-
education to promote and sustain sensitivity
to the risk for falls among hospitalized elders.
32
Conclusion
• Avoidance of unnecessary Foley catheter
placement is an important method to reduce
nosocomial infections.
• Immobilizing patients during hospitalization is
contrary to therapeutic goals of restoring
normal mobility and function as quickly as
possible.
• The number and severity of falls can be
reduced by adopting quality improvement
strategies, relevant and practical fall risk
assessment tools, and staff education.
33
Acknowledgements and
Disclaimer
This project was supported by funds from The Donald W.
Reynolds Foundation, the American Geriatrics Society/The John
A. Hartford Foundation Geriatrics for Specialists Grant. This
information or content and conclusions are those of the author
and should not be construed as the official position or policy of,
nor should any endorsements be inferred by The Donald W.
Reynolds Foundation, the American Geriatrics Society or The
John A. Hartford Foundation.
The UNC Center for Aging and Health, the UNC Division of
Geriatric Medicine, the UNC Department of Emergency Medicine,
and the UNC Department of Family Medicine also provided
support for this activity. This work was compiled and edited
through the efforts of Carol Julian.
34
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