DEPARTMENT OF

BIOCHEMISTRY
TOPIC :Functions of
Vitamin K
• NAME: PRERANA SUNIL BORSE
• ROLL NO.- 12
• CLASS – 1ST YEAR BDS
• DATE: 18/03/2023
INTRODUCTION

 Vitamins may be regarded as  organic compounds required in

the diet in small amounts to perform specific biological
functions for normal maintenance of optimum growth and
health of the organism.
 Generally, They cannot be synthesized by the body and must,
therefore, be supplied by the diet.
 CLASSIFICATION OF VITAMINS

 The vitamins are grouped into two categories based on their

solubility,
 1. Water soluble vitamins
 2. Fat soluble vitamins.
 VITAMIN K

 Vitamin K is the fat soluble vitamin

 In 1929, H Dam gave the name Coagulation vitamin from the
Danish word Coagulation. It is now called as vitamin K.
 This vitamin is called an antihemorrhagic factor as it's
deficiency produced uncontrolled hemoorrhages due to defect
in blood coagulation.
 RDA ie. Daily requirement for Vitamin K is 70-140 ug per day.
 SOURCES
 Vitamin K is present in green leafy
vegetables such as spinach, cabbage
and cauliflower.
 Vitamin K is present in vegetable oils;
olive, and soyabean oils are
particularly rich sources The vitamin is
also synthesized by microorganisms in
the intestinal tract. Approximately
50% of the daily requirement is
derived from plant sources and the rest
from bacterial synthesis.
 FUNCTIONS OF VITAMIN K

 Vitamin K plays an important role in blood coagulation.

 Vitamin K is required for the activation of blood clotting
factors, prothrombin (II), factor VII, IX, and X.
 These blood clotting proteins are synthesized in liver in inactive
form.
 They are converted to active form by vitamin K-dependent
carboxylation reaction.
 FUNCTIONS OF VITAMIN K

 In this, vitamin K-dependent carboxylase enzyme adds the

extra carboxy group at X-carbon of glutamic acid residues of
inactive blood clotting factors.
 Vitamin K is also required for the carboxylation of glutamic
acid residues of osteocalcin, a Ca2+ binding protein present in
bone