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DEFINITION :
• Asthma is a chronic heterogeneous disease of the lower airways
characterized by chronic inflammation and airway hyper-
reactivity leading to cough, wheeze, difficulty in breathing, and
chest tightness.
• Asthma triggers
• Airborne allergens, such as pollen, dust mites, mold spores, pet dander
or particles of cockroach waste
• Physical activity
• Cold air
• Viral respiratory
infections
• Allergies
• Occupational exposures
• Smoking
• Air Pollution
• Obesity
Types of Asthma:
a. Allergic Asthma (extrinic asthma)
c. Mixed Asthma
f. Noctornal Asthma
g. Occupational Asthma
A. Allergic Asthma:
• When person come across an allergy trigger, our body makes molecules called
IgE antibodies. These trigger a series of reaction that cause swelling , runny nose
and sneezing.
• Patient history
• Physical Examination
• Chest X-ray
• Pulmonary Function Test
• Blood and Sputum Test
• Allergy Prick skin Test
• Spirometry Test
• FEV ( Force Expiratory Volume)
• FVC ( Force Vital Capacity)
Asthma diagnosis algorithm
DRUGS FOR ASTHMA:
BRONCHODILATORS: Beta-2 agonists:
• Beta-2 agonists are bronchodilators that play an important role in asthma
control and treatment of acute exacerbations.
• Cysteinyl leukotrienes are released from mast cells and eosinophils and are involved in bronchial
smooth muscle contraction and increased mucus secretion.
• It can’t be used to prevent attack of asthma because it does not affect the
constrictor action.
COTICOSTEROIDS:
• cause bronchoconstriction
Asthma comorbidities and stroke:
• Asthma is not an exception and there list of commonly encountered
comorbidities includes chronic rhinitis, chronic sinusitis/rhino-sinusitis,
gastro-esophageal reflux disease, obstructive sleep apnea/sleep-disordered
breathing, psychological disturbances (particularly depression and anxiety
disorders), chronic/recurrent respiratory infections, hyperventilation
syndrome, hormonal disturbances and other .
• There are also possible emerging comorbid conditions such as cardiovascular,
obesity, metabolic syndrome, diabetes mellitus, degenerative joint
disease/arthritis and psychiatric diseases.
• Some of these comorbidities lead to an increased risk of stroke and are highly
prevalent in asthma patient. This raises the question that the increased risk
of stroke in asthma patients may be due to confounding effect. Nevertheless,
the important point is that proper screening and diagnosis of comorbidities
in asthmatics is essential for preventing serious complications including
stroke.
Bronchial Thermoplasty:
• Bronchial thermoplasty (BT) offers a nonpharmacologic therapy for
those with asthma unresponsive to standard treatment with ICS
and bronchodilators.
• Bronchial thermoplasty is a treatment for severe asthma approved by
the FDA in 2010 involving the delivery of controlled, therapeutic
radiofrequency energy to the airway wall, thus heating the tissue and
reducing the amount of smooth muscle present in the airway wall.
INFECTIONS
AGING POPULATION
Abnormal inflammatory response of the lungs due to toxic gases.
• Pulmonary vascularchanges
Thickening of vessels
Collagen deposit
Destruction of capillary beds.
Inflammation
Cause the mucus secreting glands and goblet cells to increase in number.
Ciliary function is reduced.
Bronchial walls become thickened and lumen narrows and mucus plug the airway
Alveoli adjacent to the bronchioles may become damaged and fibrosed.
infection
• sore throat,
• fatigue (tiredness),
• fever, body aches,
• stuffy or runny nose,
• vomiting, and
• Diarrhea
• persistent cough
• cough may produce clear mucus
• shortness of breath
• coughing,
• wheezing, and
• chest discomfort.
• The coughing may produce large amounts of mucus. This type of
cough often is called a smoker's cough.
• History - medical history
• Mucus -to see whether you have a bacterial infection
• chest x ray,
• lung function tests,
• CBC
• ABG ( arterial blood gas) analysis
• IMPROVE VENTILLATION
1. BRONCHO DILATORS LIKE BETA2 AGONISTS(ALBUTEROL),
2. ANTICHOLINERGIC S(IPRATROPIUM BROMIDE-ATROVENT).
3. METHYLXANTHINES(THEOPHYLLINE,AMIN OPHYLLINE)
4. CORTICOSTEROIDS
5. OXYGEN ADMINISTRATION
⦿ BULLECTOMY
BULLAE ARE ENLARGED AIRSPACES THAT DO NOT CONTRIBUTE TO
VENTILLATION BUT OCCUPY SPACE IN THE THORAX,THESE AREAS MAY
BE SURGICALLY EXCISED
⦿ LUNG VOLUME REDUCTION SURGERY
IT INVOLVES THE REMOVAL OF A PORTION OF THE DISEASED LUNG
PARENCHYMA.THIS ALLOWS THE FUNCTIONAL TISSUE TO EXPAND.
⦿ LUNG TRANSPLANTATION
⦿ Definition:-Emphysema is defined as enlargement of the air
spaces distal to the terminal bronchioles, with destruction of
their walls of the alveoli.
⦿ Pathology :
⦿ As the alveoli are destroyed the alveolar surface area in contact
with the capillaries decreases.
⦿ Causing dead spaces (no gas exchange takes place)
Leads to hypoxia in later stages:
Respiratory acidosis