FEEDBACK REGUATED DRUG

DELIVERY SYSTEM

Presented By
Kajol M. Patil
M. Pharmacy 1st Year (2022-2024)

Department of Pharmaceutical Sciences

Rashtrasant Tukadoji Maharaj Nagpur University,
Nagpur 440-033.
CONTENTS

1. Introduction to rate controlled drug delivery system

2. Types of CRDDS
3. Advantages and disadvantages of CRRDS
4. Feedback regulated drug delivery system
a) Principle
b) Classification
c) Fundamentals
5.Conclusion
6.Reference
 SUMMARY
1.INTRODUCTION TO RCDDS
 Aim
 Concept&Design
2.TYPES OF RCDDS
i. Rate programmed DDS
ii. Activation modulated DDS
iii. Feedback regulated DDS
iv. Site targeting DDS
3.ADVANTAGES&DISADVANTAGES
4.CLASSIFICATION OF FRDDS
v. Bio-erosion regulated DDS
vi. Bio-responsive DDS
vii.Self regulated DDS
Introduction To RCDDS
AIM OF RCDDS:
✓ Controlled drug delivery system has been introduced to
overcome the drawback of fluctuating drug levels associated
with convectional dosage forms
✔ Introduced to be an ideal drug delivery system
✓ Development of novel and potent drug delivery system
✔ Development of new, better and safe drug with larger
therapeutic index.
Concept and design of RCDDS

 Controlled drug delivery system is the one which delivers

the drug at a predetermined rate, locally or systemically
for a specific period of time.
 It also implies a predictability and reproducibility in the
drug release kinetics, which means that the release of drug
ingredient from a controlled delivery system proceeds at a
rate profile that is not only predictable kinetically but also
reproducible from one unit to another.
 TYPES OF RATE CONTROLLED DRUG
DELIVERY SYSTEM

CRDDS

RATE
ACTIVATION FEEDBACK SITE TARGETING
PREPROGAMME REGULATED DDS DDS
MODULATED DDS
D DDS
 FEEDBACK REGULATED DDS
PRINCIPLES:
 In this, the release of drug molecules from the delivery system is
activated by triggering agents such as a biochemical substance in the
body via feedback mechanisms.
 Rate of drug release is synchronized by the concentration of
triggering agent that is detected by a sensor in the feedback regulated
mechanisms.
 Principally, feedback DDS concept for drug delivery has been applied
to:
i. Bio erosion regulated drug delivery system
ii. Bio responsive drug delivery system
iii. Self-regulating drug delivery system
Fig: Feedback regulated drug delivery system
CLASSIFICATION OF FRDDS

BIO-EROSION REGULATED
DDS

TYPE
TYPE
BIO RESPONSIVE DDS
S
S
SELF-REGULATING DDS
1. BIOEROSION REGULATED DDS

• Developed by Heller and Trescony.

• This system consisted of drug dispersed bioerodible matrix
Consists from poly(vinyl methyl ether) half ester, which is
coated with layer of immobilized urease.
• In a solution with near pH, the polymer only erodes very slowly.
• In presence of urea, urease at the surface of drug delivery system
metabolizes urea to form ammonia. This causes the pH to
increase and a rapid degradation of polymer matrix as well as the
release of drug molecules.
• Example: Urea activated hydrocortisone
EXAMPLE: Urea activated hydrocortisone
2.BIORESPONSIVE DRUG
DELIVERY SYSTEM
• The feedback regulated drug delivery concept has also
been applied to the development of a bioresponsive drug
delivery system by Horbett et al.
• Drug reservoir is contained in device enclosed by
bioresponsive polymeric membrane whose drug
permeability is controlled by the concentration of
biochemical agent in the tissue where the system (control
drug delivery system) is located.
EXAMPLE:
Development of glucose triggered
insulin delivery system
• In this system, the insulin reservoir is encapsulated within
hydro gel membrane having -NR2 group.
• In alkaline solution, the -NR2 are neutral and the
membrane is unswollen and impermeable to insulin.
• Glucose penetrates into the membrane, it oxidizes
enzymatically by the glucose oxidase entrapped in the
membrane to form gluconic acid.
• The-NH2 group is protonated to form -NR2H+ and the
hydro gel membrane then becomes swollen and permeable
to insulin molecules.
Fig: Bioresponsive drug delivery system
3.SELF REGULATING DRUG DELIVERY
SYSTEM
 This type of system depends on a reversible and compitive
binding mechanism to activate and to regulate the release of
drug.
 Drug reservoir is drug complex encapsulated within a semi
permeable polymeric membrane.
 The release of drug from the delivery system is activated by
the membrane permeable of biochemical agent from the tissue
in which the system is located.
EXAMPLES:
 In the complex of glycosylated insulin concanavalin A,which
is encapsulated inside a polymer membrane.
 Glucose penetrates into the system and it activates the release of
glycosylated insulin from the complex for controlled delivery
out of system.

Fig: Self-regulating Insulin Delivery Systems

CONCLUSION
• Feedback regulated approaches havebeen used
effectively in insulin release in response to
changing glucose level forfor diabetic treatment
• However relatively limited work has been done in
area of opioid overdose.
REFERENCE
1.Chein Y.W; Novel drug delivery system; Fundamental of rate controlled
drug delivery; edition 2nd; page no 33-37
2.ROBINSON, "FUNDAMENTALS OFCONTROLLED DRUG
DELIVERYSYSTEM", PAGE NO. 482-508> Fundamentals of controlled
release drug delivery-Robinson, Pg.no: 482-508>
3. Indo American Journal of Pharmaceutical Science(IAJPS)- Controlled
delivery system- A review
4. Controlled release drug formulation in pharmaceuticals: A study on
their application and properties; World Journal of Pharmaceutical
Research, Volume 5, Issue 2, 1704-1720.
THANK YOU