Let’s Talk About Side Effects:

Benefits and Risks of Mental

Illness Medication

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CP-TD-US-0158 06/17
 Today’s Discussion

The Trends in TD Overview TD Incidence Let’s Talk

Mental Health & Prevalence About TD
Medication

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The Trends in Mental Illness Medication
 Medications Play an Important Role in Treating Mental Health
Conditions
• Antipsychotics, which have broad utility in
patients with severe mental illness, have seen
their usage increase over the past two
decades.
• However, these drugs may produce serious
side effects that can range in intensity from
mild to severe.
• As the severity of side effects increase, it is
important to work with your doctor to manage
your medications.
• The burden of side effects contributes to
noncompliance.
• Often, this burden is not fully recognized and,
therefore, reduces the overall effectiveness of
a given agent. Be sure to work with your
doctor when you experience side effects.

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 What are the Most Common Side Effects?
Antidepressants Anti-Anxiety Medications Antipsychotic Medications
Nausea Nausea Drowsiness
Increased appetite and weight gain Blurred vision Dizziness
Insomnia Headache Restlessness
Fatigue and drowsiness Confusion Weight gain (the risk is higher with some atypical
antipsychotic medicines)
Sexual problems Tiredness Dry mouth
Dry mouth Nightmares Constipation
Blurred vision Nausea
Constipation Vomiting
Dizziness Blurred vision
Agitation Low blood pressure
Irritability Uncontrollable movements, such as tics and
tremors (the risk is higher with typical antipsychotic
medicines)
Anxiety Seizures
A low number of white blood cells, which fight
infections

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Tardive Dyskinesia Overview
 What is Tardive Dyskinesia?
• TD is a condition characterized by
involuntary movements developing in
association with the use of a dopamine
receptor blocking agent (DRBA) for at
least a few months
– Regions affected: generally the
tongue, lower face and jaw, and
extremities

• Involuntary movements that persist 4-8

weeks after DRBA discontinuation,
change or reduction in dose are
considered TD

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 Dopamine Receptor Blocking Agents (DRBAs) Have the
Potential to Cause TD
Drug Classes Conditions Used to Treat
Antipsychotics • Schizophrenia
• Bipolar disorder
• Adjunctive treatment for major depressive disorder;
treatment-resistant depression

Antiemetics and other drugs used for • Indigestion or upset stomach

gastrointestinal (GI) disorders • Nausea and vomiting

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 TD Must Be Differentiated from Several Movement Disorders
that May Be Associated with DRBAs

Acute reactions Acute dystonia

Acute (subacute) akathisia
Acute (subacute) parkinsonism
Tardive syndromes Withdrawal emergent syndrome
Classic tardive dyskinesia
Tardive dystonia
Tardive akathisia
Tardive myoclonus
Tardive tremor
Tardive tics
Tardive chorea

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 Examples of Dyskinesia by Body Region

Oral and Facial Dyskinesia
Abnormal tongue and lip movements
Retractions of the corners
of the mouth
Abnormal eyeline
movement or twitching
Bulging of the cheeks
Chewing movements

Trunk Dyskinesia
Shoulder shrugging

Axial dystonia

Limb Dyskinesia
“Piano-playing” finger
movements
Rocking and swaying
Tapping foot movements movements
Dystonic extensor postures Rotatory or thrusting hip
of the toes movements

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 TD Can Affect Multiple Regions of the Body and Has Several
Distinct Presentations
Lip smacking, Jaw distension, Tongue movement or
pursing, or puckering chewing, or grimacing protrusion

Trunk and limb movements Blinking

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 Factors Associated with Increased Risk for TD

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 TD Is Estimated to Affect at Least 1 in 10
Patients Exposed to Antipsychotics

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Let’s Talk About TD
FOR MORE INFORMATION VISIT

TalkingAboutTD.com