From “Clarinet”, which need a very good

respiratory flow to play

CLARENCE
Probable launching
October 2018 DOXOFYLLINE

SAJIB SAHA, PM, SMD

BRAND ORIENTATION: MARKET ANALYSIS:
Brand Name: Clarence
Generic Name: Doxofylline INN
Competetion Molecule Market Value
Brand Slogan: Dependable, Safe, And Tolerant
Dosage form: Tablet, Syrup Direct Doxofylline 65 Cr.

Strength: 200mg, 400mg, 100mg/5ml Indirect Theophylline 20 Cr.

Therapeutic class: Methylxanthine Total 85 Cr.

Price : TBD
COMPETITION
BRAND COMPANY VALUE (Cr.) SHARE % GROWTH %

DOXIVA NIPRO 18.2 28.03 19.35

DOCOPA ARISTO 18.0 27.83 86.23
DOXOVEN BEACON 8.7 13.41 55.42
BREZOFIL INCEPTA 5.26 8.13 50.90
PULMODOX UNIMED 4.65 7.16 101.00
DOXIMAR ACI 2.13 3.28 50.56
DOXOFYL POPULAR 1.42 2.19 999.00
FLINDOF SQUARE 1.31 2.02 999.00
FIXOLIN BEXIMCO 1.11 1.72 999.00
DOXOMA DRUG 0.79 1.23 61.40
 DOXOFYLLINE M/A
 

• Doxofylline is a selective
phosphodiesterase inhibitor
(PDE4).

• Doxofylline selectively inhibit

phosphodiesterase (PDE)
enzyme which is responsible
to break down of cAMP
(Cyclic Adenosine mono
phosphate) to AMP.

 inhibit Phosphodiesterase (PDE) enzyme - Bronchodilation

 do not bind with Adenosine receptor – Less side effect.
 DOXOFYLLINE

Differs from theophylline, due to the ring structure in

N-7 Position. Due to this Dioxolane ring , Doxofylline shows less
side effect, like Tremor, Palpitation.
DOXOFYLLINE
No activity on adenosine receptor

Receptor Affinity
Aminophylline Theophylline Doxofylline
1.71 1.00 0.15

Result:

 Less sleep Disturbance

 Less Tachycardia
 DOXOFYLLINE
Theophylline Significant increase % FEV1
significantly increase Change in COPD patients.
Heart rate. But
Doxofylline do not.
DOXOFYLLINE
Comparative Reduction in Dispnoea score in Asthma Patients
 At Rest
 On Effort
DOXOFYLLINE
Effect on Spiro metric variables in COPD Patients
DOSAGE & ADMINISTRATION
• ADULT: 400 MG (1 TABLET) DAILY IN THE EVENING. IN ELDERLY
PATIENT WITH CONCOMITANT CARDIOVASCULAR, HEPATIC AND
RENAL DISEASES RECOMMENDED DOSE SHOULD BE 200 MG TWICE
DAILY.

• CHILDREN ABOVE 6 YEARS OF AGE: THE RECOMMENDED DOSE

OF DOXOPHYLLINE IS 6 MG/KG TWICE DAILY. THE DOSE MAY BE
INCREASED UP TO 18 MG/KG DAILY ON THE BASIS OF CLINICAL
RESPONSE.
TARGET DOCTOR
• Chest specialist
• Cardiologists STRATEGIC ACTIONS
• Medicine specialist
• Expecting healthy shelving.
• General physicians
• Pediatricians • As we developed good relation with
respiratory customer, make a good entry with
PREGNANCY cake and flower.

CATEGORY • Promote the message with regular reminder.