Professional Documents
Culture Documents
(GBS)
Prepared by
Dr. Madiha Anees PT
Asst. Prof/VP RCRS
MS-PT, BS-PT
Content
Introduction
Incidence
Classification
Pathophysiology
Causes
Risk factors
Symptoms
Diagnosis
Managment
Introduction
Guillain Barre Syndrome (GBS) or Landry's paralysis is a serious disorder that occurs
when the body’s defense (immune) system mistakenly attacks part of the peripheral
nervous system.
It is an acute, progressive, autoimmune, inflammatory demyelination of polyneuropathy of
the peripheral sensory and motor nerves and nerve roots.
The syndrome is named after the French physicians Georges Guillain and Jean Alexandre
Barré and strohl. who described it in 1916.
INCIDENCE
Rare variant
Manifest as a descending paralysis.
Usually affects the eye muscles first and
presents with the triad of ophthalmoplegia,
ataxia, and areflexia.
3) Acute Motor Axonal Neuropathy (AMAN)
Experts believe the foreign agent (bacterium/virus) causes the body's immune system to
attack the myelin sheath of the peripheral nerves.
The sheath becomes damaged, causing nerve damage, resulting in faulty sending of signals
between nerves and muscles.
This faulty wiring causes muscle weakness, numbness and tingling, and eventually
paralysis.
Risk factors
Pain
Progressive Muscle weakness
Numbness
Loss of reflexes in arms and legs
Low blood pressure
Uncoordinated movement
Facial weakness
Clumsiness and falling
Severe pain in the lower back
Sensation changes
Tenderness or muscle pain
Blurred vision
Respiratory problems
DIAGNOSTIC EVALUATION
Medical history
Physical examination
Tests -
Nerve conduction studies (NCS)
CSF examination
Electromyography (EMG)
Electrocardiogram (ECG)
Pulmonary Function Test (PFT)
Medical management