Chronic Lyme Disease

Name: Razeen Riyasat Ali

ID: 20180014
What is Lyme
disease
• Lyme disease is caused by Borrelia
burgdoferi and cases of it has been
frequently noted in USA, Europe,
China, Japan and Australia
• The organism B.burgdoferi is
transmitted to humans via bite of
infected ticks.
• When this spirochete enters the
body, it triggers an immune
response and the damage the body
faces is the result of an immune
mediated damage.
Symtoms of Lyme Disease?
• 3 stages:
Early Localised disease:
- Red Bull’s eye rash
- Myalgia
- Fever, Headache, general lymphadenopathy
Early Disseminated Disease:
- lymphocytic meningitis
-Myalgia
- Facial Palsy
- Radiculopathy
Late Disease:
- Arthritis
- Polyneuritis
- Encephalopathy
-Myalgia
Diagnosis Of Lyme Disease?
• Antibody detection
• Blood Tests
• Biopsies of Skin and Synovium
• CSF analysis
 • CDC defines CLD as
• “Chronic Lyme
What is disease” is a
nonspecific
Chronic diagnosis without a
•.

consistent definition
Lyme that has been given
Disease? to patients with
various symptoms”
• . Treatments offered
for chronic Lyme
disease, such as
prolonged antibiotic
or immunoglobulin
therapy, lack data
supporting
effectiveness and
are not
How do you Diagnose Chronic Lyme
Disease?
• Clinical Symptoms of “Lyme disease”
• History of possible tick exposure to an area endemic to Lyme disease.
• Negative Lab Tests.
Differential Diagnosis
• Chronic Fatigue Synrome
• Fibromyalgia
• Post-Treatment lyme Disorder
Treatment
• IV infusions of hydrogen peroxide
• Immunoglobulin therapy
• Hyperbaric oxygen therapy
• Stem cell transplants
Is Treating CLD with prolonged duration of antibiotics a good
decision?
So what is Post-Treatment Lyme Disease?
• Lyme disease positive patient who went through treatment, however
symptoms of pain, fatigue, or difficulty thinking lasted for more than 6
months after they finish treatment.
• Patients with PTLDS usually get better over time, but it can take many
months to feel completely well.
Conclusion
• Chronic Lyme disease is a poorly defined diagnosis that is usually
given to patients with prolonged, unexplained symptoms or with
alternative medical diagnoses
• There is no systematic evidence that Borrelia burgdorferi, the etiology
of Lyme disease, can be identified in patients with chronic symptoms
following treated Lyme disease
• Extended courses of intravenous antibiotics have resulted in severe
adverse events, which in light of their lack of efficacy, make them
contraindicated.
Reference
Centers for Disease Control and Prevention. 2021. Post-Treatment Lyme Disease Syndrome |
CDC. [online] Available at: <https://www.cdc.gov/lyme/postlds/index.html#:~:text=Although
%20most%20cases%20of%20Lyme,Lyme%20Disease%20Syndrome%20(PTLDS).> [Accessed 9
March 2021]

M Lantos, P., 2011. Chronic Lyme disease: the controversies and the science. [online] National
Library of Medicine. Available at: <https://pubmed.ncbi.nlm.nih.gov/21810051/> [Accessed 9
March 2021].

Centers of Disease Control and Prevention. 2017. Serious Bacterial Infections Acquired During
Treatment of Patients Given a Diagnosis of Chronic Lyme Disease — United States. [online]
Available at: <https://www.cdc.gov/mmwr/volumes/66/wr/mm6623a3.htm> [Accessed 9
March 2021].
• M Lantos, P., 2015. Chronic Lyme Disease. [online] NCBI. Available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477530/>
[Accessed 9 March 2021].