PCTE Group Of Institutes

Faculty of Pharmaceutical Sciences

ANTI-ASTHMA-CORTICOSTEROIDS

SUBMITTED BY KHATIB SUBMITTED TO:

B.PHARMACY 5rd SEMESTER MS SEEMA THAKUR
ROLL NO: 2222894 ASSISTANT PROFESSOR
CONTENT

Introduction
Uses
Mechanism of action
Drugs used
References
 Introduction

Corticosteroids are a class of steroid hormones that are

naturally produced by the adrenal glands (2 small glands that sit on top
of the kidneys) in the body.

They play a crucial role in regulating various physiological

processes, including:-

• Metabolism,
• Immune response, and
• Inflammation control.
 USES
These hormones can also be synthetically produced and are commonly
used in medicine for their anti-inflammatory and immunosuppressive
properties. They are prescribed to treat a wide range of medical
conditions:-
Inflammatory conditions:
Corticosteroids are prescribed to reduce inflammation in conditions like
asthma, arthritis, and inflammatory bowel disease.

Allergic reactions:
They can help manage severe allergic reactions or anaphylaxis.
Autoimmune diseases:
Corticosteroids are used to suppress the immune system in conditions such
as lupus, rheumatoid arthritis, and multiple sclerosis.

Skin conditions:
Topical corticosteroids are applied to the skin to treat conditions like
eczema, psoriasis, and dermatitis.

Respiratory conditions:
They are often used to control symptoms in chronic obstructive pulmonary
disease (COPD) and severe cases of asthma.
 Mechanism of action

• Corticosteroids, including inhaled, systemic

corticosteroids used to treat asthma, work
through various mechanisms to help manage
asthma symptoms and reduce inflammation in
the airways. Here's an overview of their
mechanism of action:
 Anti-Inflammatory Effect.
• Corticosteroids have potent anti-inflammatory properties. They reduce the
production and release of pro-inflammatory substances in the airways,
such as histamines, leukotrienes, and cytokines.
• By dampening inflammation, they help prevent the airway narrowing and
excessive mucus production that occur during asthma attacks.

 Inhibition of Immune Response.

 Decreased Mucus Production.

• Etc.
Side effects
It's important to note that while corticosteroids can be
highly effective in managing these conditions, they also
have potential side effects, especially with long-term
use. These side effects can include weight gain,
osteoporosis, increased risk of infection, and mood changes.
 Drugs

Inheld corticosteroid
systemic corticosteroid
•Prednisone
•Prednisolone Fluticasone (e.g., Flovent)
•Methylprednisolone
•Beclomethasone Budesonide (e.g., Pulmicort)
•Betamethasone
•Dexamethasone Beclomethasone (e.g., QVAR)
•Hydrocortisone
•Triamcinolone Mometasone (e.g., Asmanex)
Prednisolone tablets
• arthritis,
• blood problems,
• immune system disorders,
• skin and eye conditions,
• breathing problems,
• cancer, and
• severe allergies.
Side effects
•Nausea, heartburn, headache,
dizziness, menstrual period changes,
• trouble sleeping, increased sweating
, or acne may occur.
Drug interaction
Some products that may interact with this drug include:
aldesleukin, other drugs that weaken the immune system (such as
azathioprine, cyclosporine, cancer chemotherapy), mifepristone,
risk of adverse effects
Drugs that can cause bleeding/bruising (including antiplatelet drugs
such as clopidogrel, "blood thinners" such as dabigatran/warfarin,
NSAIDs such as aspirin/celecoxib/ibuprofen).
References
• Calvert DN (1962). "Anti-inflammatory steroids". Wis. Med. J. 61: 403–4
• William Andrew Publishing (22 October 2013).
Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1642–1643
Thank you