Scribd Logo
Upload

Welcome to Scribd!

  • RB - Intro

    Uploaded by

    sajid aalam
    2 views5 pages
    Retinoblastoma is a rare malignant eye tumor that affects approximately 1 in 15,000 to 1 in 18,000 live births each year in the United States. It is the most common intraocular malignancy in children and responsible for 1% of cancer deaths in children under 7 years old. Retinoblastoma occurs in both a familial form, which is often bilateral, and a more common sporadic unilateral form through the loss or inactivation of both alleles of the retinoblastoma gene located on chromosome 13.

    Original Description:

    intro to retinoblastoma

    Original Title

    rb - intro

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Retinoblastoma is a rare malignant eye tumor that affects approximately 1 in 15,000 to 1 in 18,000 live births each year in the United States. It is the most common intraocular malignancy in children and responsible for 1% of cancer deaths in children under 7 years old. Retinoblastoma occurs in both a familial form, which is often bilateral, and a more common sporadic unilateral form through the loss or inactivation of both alleles of the retinoblastoma gene located on chromosome 13.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    2 views5 pages

    RB - Intro

    Uploaded by

    sajid aalam
    Retinoblastoma is a rare malignant eye tumor that affects approximately 1 in 15,000 to 1 in 18,000 live births each year in the United States. It is the most common intraocular malignancy in children and responsible for 1% of cancer deaths in children under 7 years old. Retinoblastoma occurs in both a familial form, which is often bilateral, and a more common sporadic unilateral form through the loss or inactivation of both alleles of the retinoblastoma gene located on chromosome 13.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 5

    RETINOBLASTOMA

    • Primary malignant neoplasm of the


    retina that arises from immature retinal
    cells
    • The most common malignant eye tumor
    of childhood.
    • Responsible for approximately 1% of all
    deaths from carcinoma in the age group
    < 7 yrs of age
    EPIDEMIOLOGY
    • Retinoblastoma(Rb) is the most common intraocular malignancy in
    children, and affects 1 in 15,000 to 1 in 18,000 live births.
    • It represents almost 4% of all pediatric malignancies.
    • Approximately 250-300 children are newly diagnosed with
    retinoblastoma each year in the United States
    • Higher rates occur in developing countries.
    • M=F
    Occurs In Familial And Sporadic Forms
     Familial
    Bilateral – 40%
    Sporadic
    Unilateral-60%
    GENETICS
    • Loss or inactivation of both normal alleles of the
    retinoblastoma gene
    • DNA sequence localized to a small segment of
    the long arm (the q14 region) of chromosome 13

    You might also like