MISOPROSTOL

Synthetic prostaglandin E1 analogue

 INDICATIONS
Medical evacuation for first trimester missed/incomplete
miscarriage.

Medical evacuation for second trimester fetal death up to 23+6

weeks gestation.

Medical termination of pregnancy up to 22 weeks gestation.

Cervical preparation prior to surgical evacuation (up to 22

weeks)
 CONTRAINDICATIONS

Hypersensitivity to
Misoprostol or any
other prostaglandin
Molar pregnancy
agent

Underlying
Extrauterine Pelvic infection or
coagulation
pregnancy sepsis
disorder

Precautions: Previous uterine scar is not a contraindication.

ADVERSE EFFECTS

Nausea
Frequent
Vomiting
painful
Diarrhea
uterine
Abdominal
contractions
pain

Vaginal Headache
bleeding and dizziness
 DOSE ( 1 TRIMESTER)
ST

MISSED MISCARRIAGE TERMINATION OF PREGNANCY

< 13 WEEKS < 13 WEEKS

PV MISOPROSTOL PV MISOPROSTOL
800mcg 800mcg
3 HOURLY 3-12 HOURLY

2 TIMES PER 2 TIMES PER

COURSE COURSE
 DOSE (2 TRIMESTER)
nd

FETAL LOSS TERMINATION OF PREGNANCY

13+0 to 23+6 weeks 13 to 22 weeks

PV MISOPROSTOL PV MISOPROSTOL
400mcg 400mcg
4-6 HOURLY 3 HOURLY

UP TO 5 DOSES UP TO 5 DOSES
PER COURSE PER COURSE
CERVICAL PREPARATION FOR SURGICAL
ABORTION

< 13 weeks 13 to 22 weeks

PV Misoprostol PV Misoprostol 400mcg

400mcg
3-4 hours prior to
2-3 hours prior procedure
procedure
( up to 19 weeks)
 Prerequisite

Decision for use by O&G Consultant or Specialist

Usage on a named-patient basis

(to enter patient’s details in K4 Misoprostol Usage Record file)

Dosage and route of administration must be documented

clearly and prescribed on medication chart.

Medication to be inserted at least by Medical Officer