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Problem base learning (PBL )

By
PROFESSOR DR-SHOROQ AL-TEMIMI
PhD HISTOPATHOLOGY
PBL -1
A 25 y –old men presented with flu-like illness and sudden
attack of sever dyspnea with wheezing and cough after
ingestion the drug , patient with –ve family history to
allergen and –ve skin test . His temperature ,pulse
respiratory rate and blood pressure were nearly normal
and in between attaches he is nearly normal .

On CXR examination :-
showed mild hyperinflation .
Q/1-What is the possible diagnosis ? Example?

Q/2-Explain its pathogenesis if patient ingest aspirin ?

Q/3-What are the expected serological finding in this case ?


And what are the expected skin test ?
Q4/what are key inflammatory cells found in non atopic
asthma ?
PBL-2
A 50-year-old man dies following a severe episode of
status asthmaticus .He has positive family history and
positive serological test .
Q1/What are the microscopical examination of the lung at
autopsy ?
Q2/Serological finding?
Q3/Sputum finding?
Q4/Other test for asthma ?
Q5/Key cell for acute phase reaction and key cell for late
phase reaction?
Q6/Type of hypersensitivity , antibodies ,type of T helper
cell .
Q7/Pulmonary function test ( FEV1 and FVC and the ratio
Just like I told you,
You must learn

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