GENE EDITING

By - Mohit Sharma
WHAT IS GENE EDITING
GENOME EDITING IS A METHOD
THAT LETS SCIENTISTS CHANGE
THE DNA OF MANY ORGANISMS,
INCLUDING PLANTS AND ANIMALS.
EDITING DNA CAN LEAD TO
CHANGES IN PHYSICAL TRAITS,
LIKE EYE COLOR, AND DISEASE
RISK
METHODS OF GENE EDITING
1. Restriction enzymes
2. Zinc finger nucleases
3. Transcription activator
4. CRISPR-Cas9 gene editing
5. Base editing
6. Prime editing
7. PASTE: ‘Drag-and-Drop’ Editing for
Large Insertions
 Application of gene editing
Genome editing is widely used in studies of a variety of
organisms. For example, CRISPR is used to make "knockout"
models of disease in a wide range of animals, enabling
researchers to study the underlying genetic causes. It also is
being used to change genes in certain tissues or organs,
facilitate the study of diseases by focusing on culprit genes,
create cell models of disease such as in human pluripotent
stem cells and inactivate viruses in pigs so that pig organs
could potentially be used as a source of replacement organs
for humans
 MEDICAL
BREAKTHROUGHS
Genome editing technologies represent a major breakthrough that
has dramatically altered strategies in a wide range of biological
studies. Genome editing simplifies and accelerates the creation of
animal disease models and enables the construction of models in
most animal species, even those that are not amenable to
conventional gene targeting technology.
 CONCLUSION
The conclusion of gene editing is that it represents a
groundbreaking and transformative technology with the potential
to revolutionize various fields, particularly biotechnology, and
medicine. Gene editing techniques, such as CRISPR-Cas9, have
provided scientists with powerful tools to make precise
modifications to the DNA of living organisms, offering immense
possibilities for addressing genetic diseases, enhancing
agriculture, and advancing numerous other applications.