Assay of Sodium chloride IP

Procedure
Preparation of 0.1M silver nitrate
Dissolve 16.9 g in sufficient water to produce 1000ml.

Standardization of 0.1M silver nitrate

0.5844 g NaCl in 100 mL VF, diluted with DW.

20 mL NaCl in 250 mL conical flask , 1 mL of potassium chromate

indicator.
Stir and titrate with silver nitrate solution.
Till red tinge obtained.
Preparation of 0.1M Ammonium thiocyanate
Dissolve 7.612g of Ammonium thiocyanate in sufficient water to produce 1000ml.

Standardization of 0.1M Ammonium thiocyanate

Pipette 30 ml of 0.1M silver nitrate into a glass stoppered flask ,dilute with 50ml of water,
add 2ml of nitric acid and 2ml of ferric ammonium sulphate solution and titrate with
ammonium thiocyanate soluition to first appearance of red-brown colour.
Assay of sodium chloride

Dissolve 0.6 g in 50 ml of water, final volume make up to 100 mL in VF.

Take 25 mL of sample + Add 50 ml of 0.1M silver nitrate, 5 ml of 2M nitric acid

and 2 ml of dibutyl phthalate, shake well and titrate with 0.1M ammonium
thiocynate using 2 ml of Ferric ammonium sulphate solution as indicator, until
the colour becomes reddish yellow.

Reference
Indian Pharmacopoeia 2014; Vol. III; Pg. No. 2740-2741