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  • Sequence of Events

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    Hendi Gaming
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    The document outlines a sequence of events that can lead to pulmonary fibrosis in a male smoker with a history of tuberculosis. Occupational exposure and injury to lung epithelial cells activates macrophages and fibroblasts, causing the release of factors that damage the lungs and decrease the immune response. This allows a tuberculosis infection to take hold, perpetuating a cycle of inflammation, scarring, and reduced lung function that results in pulmonary fibrosis.

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    SOE (1)

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    The document outlines a sequence of events that can lead to pulmonary fibrosis in a male smoker with a history of tuberculosis. Occupational exposure and injury to lung epithelial cells activates macrophages and fibroblasts, causing the release of factors that damage the lungs and decrease the immune response. This allows a tuberculosis infection to take hold, perpetuating a cycle of inflammation, scarring, and reduced lung function that results in pulmonary fibrosis.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    1 views1 page

    Sequence of Events

    Uploaded by

    Hendi Gaming
    The document outlines a sequence of events that can lead to pulmonary fibrosis in a male smoker with a history of tuberculosis. Occupational exposure and injury to lung epithelial cells activates macrophages and fibroblasts, causing the release of factors that damage the lungs and decrease the immune response. This allows a tuberculosis infection to take hold, perpetuating a cycle of inflammation, scarring, and reduced lung function that results in pulmonary fibrosis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 1

    Male, old age, light

    smoker, occupational
    exposure, history of TB
    Pulmonary
    Epithelial injury
    Endothelial
    Activated
    proinflammatory and
    profibrotic factors,
    Decrease Immune
    System
    disfunction
    Sequence
    of Events
    macrophages, neutrophils Hypertension
    & myofibroblasts. Infection of TB
    (Lung TB relapse)
    TGF-β & ECM
    (extracellular
    Matrix) Activation of macrophages
    infected with bacilli
    Type I and II
    alveolar cell damage Release inflammatory
    cytokines (TNF-a, IL-1, IL-6)

    Colagenation and
    hyalination Night
    Accumulation Alteration of brush ↓ Appetite Fever
    inflammatory mediators border activity and/or sweats
    Pulmonary and necrotic tissue in lung structure
    Fibrosis
    Release of ↓ Intake
    Decreased of chemoreceptor
    elasticity Irritating trigger zone
    airway
    ↓ Bodyweight
    Nausea
    Shorthness of ↑ Mucus
    Chronic cough
    Breath production

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