Biochemistry of

Alzheimer's
disease

Lecturer: Matrona Chachua

Made by: Mariam Nikuradze
Anna Sandukhadze
Dea putkaradze
What is the Alzheimer's disease?
Amyloid Beta (AB) peptides
Amyloid Beta (AB) peptides
Tau proteins;
role/significance
Hyperphosphorylation
Cholinergic dysfunction

Patients with AD always

have degeneration of
deep and early basal
forebrain cholinergic
neurons
 Oxidative Stress

Oxidative stress contributes to AD pathophysiology by

causing dysfunction of neuronal mitochondria
Inflammation

Inflammation clearly
occurs in pathologically
vulnerable regions of
the Alzheimer's
disease (AD) brain
 Apolipoprotein E (ApoE)

apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD)
Synaptic Dysfunction
 Metal ion Dysregulation

Mounting evidence
revealed that the metal
ions (iron, copper, and
zinc) were dysregulated
in the susceptible brain
regions of AD patients
Mitochondrial Dysfunction
Proteostasis

Proteostasis dysfunction and

tauopathy in Alzheimer's
disease disrupts neurons that
regulate the sleep–wake cycle
 Autophagy and Lysosomal dysfunction

dysfunction of autophagy is suggested to

lead to the accretion of noxious proteins in
the AD brain
Glutamate excitotoxicity
Thank you for your attention!