Scribd Logo
Upload

Welcome to Scribd!

  • Pathophysiology of Alzheimer

    Uploaded by

    Michael Roland
    53 views1 page
    Risk factors for Alzheimer's disease include advancing age, neurotransmitter deficiencies, repeated head trauma, and a specific genotype. The amyloid hypothesis proposes that abnormal amyloid protein precursor cleavage releases amyloid beta which forms plaques, while the vascular hypothesis links aging, vascular risks, and hypoperfusion to energy crisis in brain cells. Neurodegeneration occurs through mechanisms like the cholinergic hypothesis of neuron loss and the glutamatergic hypothesis of NMDA receptor activation interfering with calcium regulation and tau protein phosphorylation.

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Risk factors for Alzheimer's disease include advancing age, neurotransmitter deficiencies, repeated head trauma, and a specific genotype. The amyloid hypothesis proposes that abnormal amyloid protein precursor cleavage releases amyloid beta which forms plaques, while the vascular hypothesis links aging, vascular risks, and hypoperfusion to energy crisis in brain cells. Neurodegeneration occurs through mechanisms like the cholinergic hypothesis of neuron loss and the glutamatergic hypothesis of NMDA receptor activation interfering with calcium regulation and tau protein phosphorylation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    53 views1 page

    Pathophysiology of Alzheimer

    Uploaded by

    Michael Roland
    Risk factors for Alzheimer's disease include advancing age, neurotransmitter deficiencies, repeated head trauma, and a specific genotype. The amyloid hypothesis proposes that abnormal amyloid protein precursor cleavage releases amyloid beta which forms plaques, while the vascular hypothesis links aging, vascular risks, and hypoperfusion to energy crisis in brain cells. Neurodegeneration occurs through mechanisms like the cholinergic hypothesis of neuron loss and the glutamatergic hypothesis of NMDA receptor activation interfering with calcium regulation and tau protein phosphorylation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Pathophysiology of Alzheimers Disease

    Risk factors: 1. Advancing age 2. Neurotransmitter deficiencies 3. Repeated head trauma 4. Apolipoprotein Epsilon 4 genotype

    Causes: Unknown

    Amyloid Hypothesis Abnormal amyloid protein precursor cleavage Single strands of insoluble Bamyloid is released in the extracellular space and Forms plaques

    Vascular Hypothesis Advancing aging and vascular risk factor Brain hypoperfusion Neuroglial energy crisis

    Glutamatergic Hypothesis

    Cholinergic Hypothesis Loss of neurologic neurons Loss of Acetylcholine (Ach)

    N-methyl-D-aspartate (NMDA) receptors undergo sustained low level activation of the Low level of neurotransmission Chronic calcium influx within the neuron that interferes with normal signal transduction Hyperphosporylati on of tau proteins Neurofibrillary tangles formation

    Mild Cognitive Impairment

    Neurodegenerati on

    Clinical Manifestations of Alzheimers Disease

    You might also like