RISK FACTORS:

 Advance age
 Neurotransmitters
deficiencies
 Repeated head
PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE trauma
 Apolipoprtein
CAUSES: epsilon 4 genotype
UNKOWN

AMYLOID VASCULAR Glutamatergic Cholinergic

HYPOTHESIS HYPOTHESIS Hypothesis Hypothesis

Advancing in aging N-methyl-D aspartate

Abnormal amyloid (NMDA) receptors undergo
and vascular risk
protein precursor sustained low level activation
factors of the brain.
cleavage
neurotransmission
Brain
hypoperfusion
Single strands of Loss of neurologic
insoluble b-amyloid Low level of neurons
is release in the Neurolgialenergy neurotransmission
crisis
Forms plaques
Chronic Calcium reflux
within the neuron that infers
Mild cognitive with normal signal
Increase anxiety Loss of
impairment transduction.
Difficulty organizing thoughts and acytylcholine
thinking logically (Ach)
Shortened attention span Hyperphosporylati
Problems coping with new Neuro- on of tau proteins
situation degeneration
Wandering/getting lost
Taking longer to complete daily
Poor judgement Neurofibribillary
task
Memory loss tangles formation
Repeating questions things
Loosing/misplacing
Loss of spontancity
 MILD ALZHIMERS DISEASE

- REFERENCE: slideshare m-_sumbe,

- Niah.nih.gov
- Module NCM105week 13