Drugs used in Dyspepsia

Dyspepsia

• Dyspepsia, the medical term for indigestion,

refers to discomfort or pain in the upper
abdomen, often after eating or drinking. It is not
a disease but group of symptoms, like heart
burn, bloating ,nausea , regurgitation ,fullness.
• Lifestyle tips and medication can help manage it.
 Drugs that inhibit gastric acid secretion

H2 receptor blockers: Cimetidine, Ranitidine

Proton pump inhibitors: Omeprazole, Pantoprazole

Anticholinergics : Pirenzepine

Prostaglandin analogues: Misoprostol

 Drugs that neutralize gastric acid (Antacids)

Systemic:

• Sodium bicarbonate, sodium citrate

Non systemic:

• Magnesium hydroxide, Mag. Trisilicate,

Aluminium,hydroxide gel, Magaldrate
• Magnesium

• Diarrhea, dehydration, hypermagnesemia, renal stones

• Aluminum

• Constipation, intestinal impaction, anorexia, weakness

• Calcium carbonate

• Constipation, rebound hyperacidity, metabolic

• alkalosis, hypercalcemia, renal stones, fecal impaction

• Sodium bicarbonate:

• Systemic alkalosis, sodium overload

 CONTRAINDICATIONS

• Magnesium

• Renal insufficiency

• Aluminum

• Gastric outlet obstruction

• Sodium

• Hypertension, CHF, sodium restricted diets

 Prokinetic drugs
A prokinetic agent (also gastroprokinetic
agent, gastrokinetic agent or propulsive) is a type
of drug whichenhances gastrointestinal motility
by increasing the frequency or strength of
contractions, but without disrupting their
rhythm.
 Prokinetic drugs
1.Metoclopramide
2.Domperidone
They both are dopamine antagonists.
3.Erythromycin a macrolid is also a prokinetic
agent activates the motilin receptors in G.I.T
4. Benzamides such as mosapride and cisapride,
5-HT4 receptor Agonists
 1
A patient was on antacid and he
develops constipation which antacid can cause
this?

A. Magnesium trisilicate
B. Magnesium hydroxide
C. Calcium carbonate
D. Sodium bicarbonate
E. Aluminum hydroxide T
 2
A patient was on antacid and he develops
diarrhea which antacid can cause this :

• A. Magnesium trisilicate
• B. Magnesium hydroxide T
• C. Calcium carbonate
• D. Sodium bicarbonate
• E. Aluminum hydroxide
 3
Which antacid is known as systemic antacid :

• A. Magnesium trisilicate
• B. Magnesium hydroxide
• C. Calcium carbonate
• D. Sodium bicarbonate T
• E. Aluminum hydroxide
 4
Prokinetic drug inhibits the dopamine receptor is?
A. Metoclopramide T
B. Erythromycin
C. Mosapride
D. Cisapride
E. Tegaserod
 5
Prokinetic drug activate Motilin receptor in GIT is?
A. Metoclopramide
B. Erythromycin T
C. Mosapride
D. Cisapride
E. Tegaserod