VON

WILLEBRAND’S
DISEASE
Platelets Disorder
DEFINITIO
N
Von Willebrand’s disease is the most common
hereditary bleeding disorder caused by a deficit of Von
Willebrand’s factors
Considered a type of hemophilia
VWD factors VII is a large glycoprotein presents in plasma
and endothelium and binds other protein
 Vessel Injury

Platelets Adhesion and Aggregation

Inherited Disorder
Autosomal Dominant Inheritance Recessive Inheritance
VWD
Type 1: Partial Type 2 : Impaired VWF Type 3: Severe , Near total
deficiency of VWF production absence of VWF

Reduce VWF function

1. Prolong bleeding
Reduce Platelets Plug Formation
2. Epistaxis
3. Bleeding from mucosal Reduce VWF
Reduce Factor VIII levels Antigen essay
4. Skin bleeding
5. Easy bruising
6. Menorrhagia Abnormal Clot structure
7. Spontaneous hematomas

Desmopressin
VWF VIII replacement Therapy
Antifibrinolytic
Hormonal Therapy
TYPES OF
VWD
LAB/DIAGNOSTIC EXAM
1. Screening test
2. CBC test
3. Activated Partial Thromboplastin test (APTT)
4. Prothrombin test (PT)
5. Factor VIII Clotting activity Test
6. Von Willebrand’s disease antigen
7. Von Willebrand’s factor multimers
8. Platelets aggregation tests
NURSING MANAGEMENT
THANK YOU!