A company has discovered a candidate compound that is highly selective

and potent H1 receptor inhibitor. The drug is rapidly absorbed in the gut but
is also rapidly excreted in the urine, and so it need to be taken every 30
minutes to be effective. Which of the following statements is most correct:

A) This drug has a poor pharmacodynamic profile

B) This drug has significant on-target side effects
C) This drug has a poor pharmacokinetic profile
D) This drug is likely a prodrug
E) This drug causes activation of the H1 receptor
A company has discovered a candidate compound that is highly selective
and potent H1 receptor inhibitor. The drug is rapidly absorbed in the gut but
is also rapidly excreted in the urine, and so it need to be taken every 30
minutes to be effective. Which of the following statements is most correct:

A) This drug has a poor pharmacodynamic profile

B) This drug has significant on-target side effects
C) This drug has a poor pharmacokinetic profile
D) This drug is likely a prodrug
E) This drug causes activation of the H1 receptor
Terfenadine is best described as a prodrug because it:

A) promotes H1 receptor activation

B) is a pro-inflammatory compound
C) is processed by the liver when it is targeted for excretion
D) is inactive but is metabolized in body to generate its active form
E) is a higher quality formulation than the generic drug
Terfenadine is best described as a prodrug because it:

A) promotes H1 receptor activation

B) is a pro-inflammatory compound
C) is processed by the liver when it is targeted for excretion
D) is inactive but is metabolized in body to generate its active form
E) is a higher quality formulation than the generic drug
A common class of anti-epileptic drugs acts by targeting GABA A receptors in
the brain, and has the benefit of suppressing seizures. Activation of GABA A
receptors can also cause drowsiness and sedation. This is an example of a:
A) Off-target side effect
B) Pharmacogenomic profile
C) On-target side effect
D) Highly potent drug interaction
E) Pharmacokinetic consideration
A common class of anti-epileptic drugs acts by targeting GABA A receptors in
the brain, and has the benefit of suppressing seizures. Activation of GABA A
receptors can also cause drowsiness and sedation. This is an example of a:
A) Off-target side effect
B) Pharmacogenomic profile
C) On-target side effect
D) Highly potent drug interaction
E) Pharmacokinetic consideration
Which of the following statements describes a potentially relevant drug
interaction that could affect the desired effects of a therapeutic drug?

A) Inhibition of H1 receptors by fexofenadine

B) Taking fexofenadine along with a substance that inhibits metabolism of
terfenadine to fexofenadine
C) Conversion of terfenadine to fexofenadine in the liver
D) Taking terfenadine along with a substance that inhibits metabolism of
terfenadine to fexofenadine
E) Inhibition of H1 receptors by terfenadine, leading to potentially fatal
cardiac arrhythmias
Which of the following statements describes a potentially relevant drug
interaction that could affect the desired effects of a therapeutic drug?

A) Inhibition of H1 receptors by fexofenadine

B) Taking fexofenadine along with a substance that inhibits metabolism of
terfenadine to fexofenadine
C) Conversion of terfenadine to fexofenadine in the liver
D) Taking terfenadine along with a substance that inhibits metabolism of
terfenadine to fexofenadine
E) Inhibition of H1 receptors by terfenadine, leading to potentially fatal
cardiac arrhythmias
Why are pharmacokinetic principles important in drug development?

A) Pharmacokinetics refer to specific interactions of drugs with their

receptors
B) Pharmacokinetics affect the specificity of a drug:receptor interaction
C) Pharmacokinetics are used to determine how much and how frequently
a drug should be taken for maximum effectiveness
D) A poor pharmacokinetic profile likely means that a drug has off-target
side effects
E) Pharmacokinetic properties of a drug cannot be improved or altered.
Why are pharmacokinetic principles important in drug development?

A) Pharmacokinetics refer to specific interactions of drugs with their

receptors
B) Pharmacokinetics affect the specificity of a drug:receptor interaction
C) Pharmacokinetics are used to determine how much and how
frequently a drug should be taken for maximum effectiveness
D) A poor pharmacokinetic profile likely means that a drug has off-target
side effects
E) Pharmacokinetic properties of a drug cannot be improved or altered.