PHARMACOLOGY

DRUGS FOR DISORDERED

PHYSIOLOGY IN CHILDBIRTH

CARDIOVASCULAR DISORDERS IN PREGNANCY

BETA BLOCKERS
STUDENT: JACKLYN G. PACIBLE R.M
Drugs used in Hypertensive Emergencies

A. Magnesium Sulfate

B. Beta Blockers

C. Ace Inhibitors
BETA BLOCKERS

A blocking agent , one of a class of

drugs used to treat hypertension and
control the rate at which the heart beats.
 Atenolol Nebivolol
Propanolol
 Classification of Beta Blockers into 3 Generations
• Non-selective, meaning that they
First Generation blocked both beta-1 (β1) and beta-2 (β2)
Andrenoceptors.

• Beta-blockers are more

Second Generation cardioselective in that they are
relatively selective for β1 adrenoceptors.

• Vasolidating beta blockers

• have hemodynamic effects including
Third Generation decreased pressure wave reflection from
periphery,leading to decreases in
central aortic blood pressure.

β1 : located mainly in the heart and in the kidneys

β2 : located mainly in the lungs, gastrointestinal

tract,liver,uterus,vascular smooth muscle, and skeletal
muscle.
β3 : located mainly in the fat cells.
Common β-blockers Drugs
DOSAGE

HTN:40mg bid up to 240 mg/day in

2–3 divided doses
 Adrenergic Receptor Antagonists

Second
First Generation Third Generation
Generation B1 –
(Nonselective) Vasodilatory
Selective

Nadolol
Oxprenolol