THE MASSIVE

POISONING IN
CHIQUINQUIRÁ (1967)

TEAM 3
Causative chemical agent
Folidol (insecticide that is used especially to control ants in crops)

Folidol is a commercial
preparation of the
organophosphate insecticide
chemically named Methyl
Parathion, diluted
in an organic solvent (possibly n-
hexane)
 Toxicokynetics
BIOTRANSFORMATION
On bioactivation, more toxic ABSORPTION
metabolites are formen than the
parent compound. This is carried out 1. Ingestion
by cytochromes P450, through a
reaction of oxidative 2. Inhalation
desulfurization, in which the 3. Dermal route
formation of analogues of oxygen
called oxons that inhibit the enzyme
acetylcholinesterase.
DISTRIBUTIO
EXCRETION N
The main route is through the urine When the poison passes into the
and to a lesser extent through the blood, it spreads through the body
feces or the expired air. Its with which it has a greater affinity.
maximum excretion occurs at 48h.
 Toxicodynamics
01 02
NEUROLOGICAL GENETIC
Acetylcholinesterase Alkylation in DNA in
inhibition inorganic systems vitro

03 04
REPRODUCTIVE HEMATOLOGICAL
● Defects in sperm function Lipoperoxidation in cells
● Alteration of antioxidant sanguineous
systems in testicles
● Male infertility
 Clinical
manifestations
Historical context
and consequences
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