Major Endocrine Organs

HORMONAL DISEASE
DISEASE HYPER / HYPO SECRETION

GROWTH & DEVELOPMENT THYROID

METABOLISM PANCREAS

REPRODUCTION OVARIUM & TESTIS

ENERGY & NUTRITION ADRENAL

 HORMONAL DISEASE (MOST)

GROWTH DISORDERS
STRUMA ( HYPO & HIPERTHYROIDI) THYROID

DIABETES MELLITUS PANCREAS

LIPID DISORDERS

INFERTILITY
MENSTRUATION & MENOPAUSE
OVARIUM & TESTIS
CARCINOMA
OSTEOPOROSIS

HIPERTENSI ADRENAL
 Bapak kurang
minum
Waah capek hormon seks
sekali

Gara-gara hormon seks

POROS HIPOTALAMUS-HIPOPISIS-
OVARIUM/TESTIS
 Ovarian hormones
GnRH
HYPHOPHYSIS (gland) HYPOTALAMUS

FSH LH

OVARIUM

ESTROGEN ( blood stream)

PROGESTERON

UTERUS; VAGINA; MAMMA

Gonads: Female

 Paired ovaries in the abdominopelvic

cavity produce estrogens and
progesterone
 They are responsible for:
Maturation of the reproductive organs
Appearance of secondary sexual
characteristics
Breast development and cyclic changes in the
uterine mucosa
 CLINICAL USE

ESTROGEN & PROGESTERONE

MENSTRUAL DISTURBANCE NON HORMONAL ?

Hormonal contraceptive
Hypo secretion; menopause (HRT)

SIDE EFFECT / TOXICITY

PHYSIOLOGIC / BALANCE

HYPER HORMONAL
 ANTI ESTROGEN

Preparat : Clomiphen
Tamoxiphene

Clinical use: infertility ---- induce ovulation

( an ovulatoir)

Mech of action : blocking estrogen receptor

FSH & LH increase

 Mechanism of action ANTI ESTROGEN

FSH HYPHOPHYSIS (gland)

LH
OVARIUM

ESTROGEN ( blood stream) Clomiphene

PROGESTERON

UTERUS; VAGINA; MAMMA

 HYPOTALAMUS

GnRH

HYPHOPHYSIS (gland)

FSH LH

TESTIS

TESTOSTERONE ( blood stream)

Penis, Larynx, skeleton, Muscle mass

Pubic and axillary hair
Gonads: Male

 Testes located in an extra-abdominal sac

(scrotum) produce testosterone
 Testosterone:
Initiates maturation of male reproductive organs
Causes appearance of secondary sexual
characteristics and sex drive
Is necessary for sperm production
Maintains sex organs in their functional state
 CLINICAL USE

TESTOSTERONE

HYPOGONADISM, STIMULATE RBC, NON HORMONAL ?

INCREASE MUSCLE BULK
Hormonal contraceptive

SIDE EFFECT / TOXICITY

 MECHANISM OF
GLUCOCORTICOID
 Aldosteron
Fludocortisone Aminoglotethimide
Metyrapone
Spironolactone
Ketoconazole
Mifepristone
Cortisol

Prenisone,Triamcinolone

Dexamethasone
PREDNISON (STEROID)

INFLAMATION

SIDE EFFECT / TOXICITY

HYPERGLYCEMIA
CUSHING SYNDROOM
HYPERTENSION
 Regulation of Blood Glucose Levels

 The
hyperglycemic
effects of
glucagon and
the
hypoglycemic
effects of
insulin
JAGALAH KESEHATAN ANDA