• Therapeutic interventions based on hypothetic pathogenetic mechanisms of

diabetic neuropathyInterventions with inhibitory effects are marked in red, with

mainly supportive effects in green.
Common neuropathic pain syndromes originating from damage to the peripheral
nervous system (PNS)
Etiology Common syndromes
Toxic Chemotherapy-induced peripheral neuropathy (CIPN), alcoholic
neuropathy
Traumatic Complex regional pain syndrome (CRPS) type II, phantom limb pain,
post-surgical/traumatic neuropathy
Ischemic/ Diabetic painful neuropathy (DPN), vitamin B12 deficiency
metabolic
Infectious/ Post-herpetic neuralgia (PHN), human immunodeficiency virus (HIV)
inflammatory painful sensory neuropathy, chronic inflammatory demyelinating
polyneuropathy (CIDP)
Invasive/ Cancer pain, painful radiculopathy, carpal tunnel syndrome
Compressive
Heredictary Charcot-Marie-Tooth disease (CMT), erythromelalgia, paroxysmal
extreme pain disorder
• Overview of
peripheral and
central changes
contributing to
neuropathic pain