Puborectalis muscle Anatomy of the anal sphincter FUNCTION OF ANAL SPHINCTER AND PUBORECTALIS
Puborectalis: control continence over solid stool
Internal sphincter: control of liquid faeces External sphincter provide internal sphincter in times of sudden need, such as raised intra abdominal presures Anal cushion the amount of blood flowing through its arteriovenous channels provide control over flatus Sphincters Internal anal sphincter Voluntary or involuntary? • Involuntary Type of muscle? • Smooth muscle Tonically contracted Sphincters External anal sphincter Voluntary or involuntary? • Voluntary Type of muscle? • Striated muscle Nerve and segment? • Pudendal nerve (S2-S4) Bowel Neuroanatomy Neural controls Extrinsic (3) 1) Sympathetic 2) Parasympathetic 3) Somatic Intrinsic (2) 1) Myenteric plexus 2) Submucosal plexus
SNS and PNS modulate the enteric nervous
system as opposed to directly controlling smooth muscle of bowel Neuroanatomy & Physiology Autonomic neural pathways Parasympathetic • Upper via Vagus nerve innervates… – Upper segments of GI tract to splenic flexure • Lower via Pelvic splanchnic nerves (nervi erigentes) – S2-S4 to the descending colon and rectum • Function – Stimulates GI secretion, motor activity – Relaxes sphincters and blood vessels Neuroanatomy & Physiology Autonomic neural pathways Sympathetic • Hypogastric nerve – L1, L2, L3 to the lower colon, rectum, and sphincters • Function – Inhibition of GI secretion, motor activity – Contraction of GI sphincters and blood vessels Somatic • Pudendal nerve – S2-S4 – External anal sphincter and pelvic floor Bowel - Autonomic Nervous System Parasympathetics Increases colonic motility Sympathetics Promote storage • Enhance anal tone • Inhibit colonic contractions • Bilateral sympathectomy has little clinical effect Parasympathetic Control Neurotransmitter • Ach • Near the neurons of myenteric and submucosal plexuses Nerve(s) • Vagus – From esophagus to mid transverse colon • Pelvic nerve – Supplies mid-transverse colon to rectum Lack of PNS innervation to …. • Small intestine Function(s) • Increase peristalsis, stimulate secretions, relax sphincter, increase gut motility Bowel – Autonomic Nervous System Parasympathetic nervous system PNS functions • Increase peristaltis • Stimulates secretions • Relaxes sphincters • Increases gut motility Sympathetic Control Neurotransmitter Norepinephrine Location Intermediolateral SC (T5-L2) Superior and inferior mesenteric nerves (T9-T12) Hypogastric (T12-L3) Functions Decrease peristalsis Inhibits secretions Contracts sphincters Decreases gut motility Neuroanatomy & Physiology Intrinsic nervous system Submucosal (Meissner) plexus Myenteric (Auerbach) plexus Regulate segment-to-segment movement of the gastrointestinal (GI) tract May be considered a 3rd part of the ANS Intrinsic Nervous System Myenteric plexus (Auerbach) Located between the longitudinal and circular layers of muscle in the tunica muscularis Controls tonic and rhythmic contractions Exerts control primarily over digestive tract motility Submucosal plexus (Meissner) Buried in the submucosa Senses the environment within the lumen Regulates GI blood flow Controls epithelial cell function (local intestinal secretion and absorption) May be sparse or missing in some parts of GI tract Partially controlled by autonomic nervous system Intrinsic Nervous System 3 types of neurons in enteric system 1. Sensory neurons (5 types) – Chemoreceptors sensitive to acid, glucose and amino acids have been demonstrated which, in essence, allows "tasting" of lumenal contents. Sensory receptors in muscle respond to stretch and tension 2. Motor neurons • Control GI motility and secretion, and possibly absorption 3. Interneurons • Largely responsible for integrating information from sensory neurons and providing it to motor neurons Intrinsic Nervous System Enteric neurotransmitters Acetylcholine • Excitatory – Stimulate smooth muscle contraction – Increase intestinal secretions, – Release of enteric hormones – Dilation of blood vessels Norepinephrine • Derived from extrinsic sympathetic neurons • Inhibitory Functions autonomously but normal digestive function requires communication between the intrinsic system and CNS Normal Defecation Rectosigmoid distention stimulates rectorectal reflex Bowel proximal to bolus • contracts Bowel distal to bolus • relaxes
Reflex relaxation of internal anal sphincter
Rectoanal inhibitory reflex Correlates with the “urge to go” Volitional contraction of levator ani Normal Defecation Volitional control of levator ani Opens proximal anal canal Relaxes external sphincter and puborectalis Allows straighter anorectal passage May increase with Valsava Increasing intraabdominal pressure (squat) Normal Defecation Defecation deferred by volitionally contracting (2)… Puborectalis External anal sphincter Then, internal anal sphincter relaxation reflex will fade (within approx 15 sec) and urge will resolve until triggered again Normal Defecation Protective mechanisms EAS will tense in response to small colonic contractions • Via spinal cord reflex (conus) and modulated by higher centers Anatomy Perineum