A STUDY OF CORRELATION OF SERUM IRON,

FERRITIN AND TIBC IN CHRONIC KIDNEY DISEASE

PATIENTS
GUIDED BY,
AMRUTHA OK ABDUL RAHEEM
Ast. PROFESSOR 4th YEAR BSc MLT
BIOCHEMISTRY MIMS COAHS
 INTRODUCTION

The cause of anemia in chronic renal failure is multifactorial. Decreased

erythropoietin production is the main pathogenic factor, but iron
deficiency is the primary cause of unresponsiveness to erythropoietin
therapy.
The diagnosis iron deficiency is assessed the sensitivity and specificity
of serum iron, serum ferritin and serum TIBC in patient with CKD
undergoing dialysis.
 AIM & OBJECTIVES
AIM:
• To find out the correlation between serum iron, serum ferritin, serum
TIBC in CKD patient undergoing dialysis.
OBJECTIVE:
• To estimate serum iron level in renal disease patient.
• To estimate serum ferritin level in renal disease patient.
• To estimate serum TIBC level in renal disease patient.
• To correlate serum iron, ferritin and TIBC in renal disease patient.
 REVIEW

• Anemia is a complication of chronic kidney disease and may contribute to

adverse clinical outcomes[1].
• Aneamia in chronic kidney disease is mainly due to iron and erythropoietin
deficiencies and hyporesponsive to action of erythropoitein.
• Iron deficiencies in general population is a common cause of anaemia and is
prevalent in patients with diabetes and CKD .
• In these same patients dietry deficiencies ,low intestinal absorbtion and
gastrointestinal bleeding may result in absolute iron deficiency aneamia.
• In CKD both absolute and relative iron deficiency are common .
• Absolute iron defiency is defined as a depletion of tissue iron store evidenced
by a serum ferritin level,100 ng/ml or a TSAT of less than 2%.
 MATERIAL AND METHODS
•The present study is conducting at MIMS hospital, Calicut.
•We collect samples from biochemistry department.
•And estimate the amount of serum iron, ferritin and TIBC from
collected samples.
INCLUSION CRITERIA:
•CKD patients having > 18 years.
•Chronic kidney disease diagnosed by physician.
EXCLUSION CRITERIA:
•CKD patient with any type of organ transplant and bleeding disorder,
inborn errors and other type of congenital disorder.
•CKD patients undergoing iron therapy.
METHOD OF COLLECTION OF DATA
A pre structured and pretested performa was used to collect the
patients detail. Following details are collected from all subject who
participating in the study
•Baseline data including name, age, sex
•Renal history ,personal history ,family history
•Clinical examination if any,

SL NAME OF AGE GENDER ADDRESS/ NO OF AMOUNT AMOUNT AMOUNT

NO. PATIENT CLINICAL DIALYSIS IN OF SERUM OF SERUM OF SERUM
HISTORY A WEAK IRON FERRITIN TIBC
METHODS
• Estimation serum iron level by Ferrozine method
• Estimation of serum ferritin by CLIA method
• Estimation of serum TIBC level by colorimetric method
• Correlation study
 RELAVANCE

• Screening for serum iron, TIBC and ferritin in CKD must be seriously
taken in order to diagnose aneamia associated with CKD.
 EXPECTED OUTCOME

• In this study we observe important relationship between the serum

ferritin, serum iron, and serum TIBC in CKD patients.
• And we can find that CKD patients are prone to aneamia.
 REFERANCE

1. William McClellan, Stephan L Aronoff;”The prevalence of anemia in

patients with chronic kidney disease”.
2. Ana M Fernandez-Rodriguez, Maria C; “Diagnosis of iron deficiency
in chronic renal failure
• Kalander-zadeh k, Lee GH; “the fascinating but deceptive ferritin:to
measure it or not to measure it in chronic kidney disease”.
• miurkY; “serum transferrin in chronic renal failure. The relationship
between aneamia and nutrition irregular hemodialysis patients”
• Ooibs, Darocy AF, Pollack YE; “serum transferrin level in chronic renal
failure”.