TRIPLE X SYNDROME

RILEY DINEEN
SYMPTOMS OF TRIPLE X

Symptoms vary throughout each female, some get minor symptoms, some not at all, and some get major
symptoms.

Occasional Symptoms include but aren’t limited to:

● Some children develop speech and language skills later than others. This can lead to problems with motor
skills, as the children may not be able to sit up or walk easily.
● Learning disabilities like having difficulty reading or writing.
● Psychological problems such as depression and anxiety disorders.
Who gets Triple X Syndrome
● Disorder occurs only in individuals
who are born female.
● The condition is random and
unpreventable.
● Triple X Syndrome is fairly common
and occurs in about 1 in 1000 live
births.
● Most cases of Triple X Syndrome are
never diagnosed.
Causes of Triple X Syndrome
● The condition is caused by ● Karyotype showing Triple X
nondisjunction during the formation of Syndrome
reproductive cells.
● The genetic error results presence of
an extra X chromosome in each cell.
● It can also be caused by mosaicism.
● Advanced maternal age increases risk
of having a child with the condition.
Inheritance
● Most cases of Triple X Syndrome ● Triple X Syndrome pedigree
are not inherited.
● It is a random occurrence caused by
a genetic error.
● Females diagnosed with the
condition can have children who are
normal with typical chromosomal
patterns.
Treatment
● There is no specific cure for Triple X Syndrome.
● Treatment for the condition is based on specific needs and challenges of each
individual.
● Early diagnosis and intervention can be useful for children who might experience
developmental delays.
● Interventions such as developmental therapy, physical therapy, and counseling
may be necessary.
References

● Berglund, A., Viuff, M. H., Skakkebæk, A., Chang, S., Stochholm, K., & Gravholt, C. H. (2019). Changes in the cohort composition

of turner syndrome and severe non-diagnosis of Klinefelter, 47, XXX and 47, XYY syndrome: a nationwide cohort study. Orphanet

journal of rare diseases, 14, 1-9.

● Gravholt, C. H., Tartaglia, N., & Disteche, C. (2020, June). Sex chromosome aneuploidies in 2020-the state of care and research in the

world. In American journal of medical genetics. Part C, Seminars in medical genetics (Vol. 184, No. 2, p. 197). NIH Public Access.

● Medlineplus. (n.d.). Trisomy X. https://medlineplus.gov/genetics/condition/trisomy-x/

● Otter, M., Campforts, B. C., Stumpel, C. T., van Amelsvoort, T. A., & Drukker, M. (2023). Triple X syndrome: Psychiatric disorders

and impaired social functioning as a risk factor. European Psychiatry, 66(1), e7.

● Singhealth. (n.d.). Triple X Syndrome. https://www.singhealth.com.sg/patient-care/conditions-treatments/triple-x-syndrome