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interferon البحث السابع
interferon البحث السابع
production, and the A allele responsible for the low INF production .
- At First INF-ꝩ was known to posses exclusively an antitumor anti-proliferative effects by different mechanisms , But In
tumor cells and host cells, INF-ꝩ was found to induce paradoxical responses that facilitate tumor outgrowth leading
to initiation of immunosuppressive tumor microenvironment and adaptive resistance which result in tumor-specific T
cells suppression
- The effect of different cytokines gene polymorphisms in breast cancer have been documented in several studies
confirming its association to BC involvement
The study demonstrated strong association between INF- ꝩ 874 A/T polymorphism with the
aggressiveness and carcinogenesis of BC, suggesting its role in the pathogenesis of BC especially
. It may be used as practical biomarker to guide the BC carcinogenesis and risk assessment
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