Introduction to

HIV
Combination
Prevention
Training in Digital Platform
Day Three
Ikatlong araw ng pagsasanay
SHORT QUIZ

How does a condom

prevent HIV infection?
Paano nakakaiwas sa HIV
infection sa paggamit ng
condom?

HIV Combination Prevention

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SHORT QUIZ

Where can one get an

HIV screening/test?
Saan pupunta upang
magpa HIV screening o
testing?

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 SHORT QUIZ
Do you need the
permission of your
parents to get tested for
HIV?
Kailangan ko bang magpaalam sa
magulang ko para magpa- HIV
screening/testing?

HIV Combination Prevention

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 Pre &
Post
Exposure
Prophylaxis

PrEP & PEP

Prophylaxis
• An action to prevent a disease

To prevent cavities To prevent rabies

PRE EXPOSURE POST
 (PrEP)
Pre-exposure Prophylaxis

Ang Pre-exposure prophylaxis ay

paraang inirerekomenda sa mga
taong walang HIV nguni’t
malaki ang chance na
magkaroon.

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Partner is PLHIV STI in the past 6 Exchanged money,
who is taking mos gifts, drugs, or
effective favors for sex
medications

Unprotected sex Used drugs or alcohol for

with more than one sexual pleasure in the past
partner 6 months
 (PrEP)
Pre-exposure Prophylaxis

Ito ay pildoras na nagbibigay ng

proteksyon laban sa HIV bago pa
man ma-expose sa HIV.

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HOW DOES PREP WORK?
HOW DOES HIV HAPPEN?
 CD4 T CELL
HIV

C K!! !
HIJA
 (PrEP)
Pre-exposure Prophylaxis

Nagbibigay ng malaking
proteksyon laban sa HIV ang
PrEP (for receptive anal
sex (bottoming) sa 7 araw na
walang palyang pag-inom ng
gamot araw-araw).

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 (PrEP)
Pre-exposure Prophylaxis

Para sa receptive vaginal

sex and injection drug use, ang
bisa ng PrEP ay lalakas makaraan
ang 21 araw na walang palyang
pag-inom.

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 (PrEP)
Pre-exposure Prophylaxis

Ito ay pildoras na nagbibigay ng

proteksyon laban sa HIV bago pa
man ma-expose sa HIV.

9.9 % o
9epekti HIV
b
n s a
la ba
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 STUDY POPULATION REGIMEN EFFICACY COMMENTS
iPrEx 2007 2499 MSM & TG 1251 – TDF + FTC 44% 99% efficacy among
R/DB/PCT 1248 – Placebo compliant

Partners PrEP 4578 heterosexual 1579 – Truvada 75% 90% efficacy among
2008 serodiscordant 1584 – Viread 67% compliant
1584 - Placebo

TDF -2 study 1200 MSM & women 601 Truvada 78%

2007 599 Placebo

PROUD 544 gay & other MSM 275 PrEP Immediately 86% Patients who had acute
2012 with anal intercourse in 269 PrEP 1yr deferral infection when PrEP was
last 90 days initiated had the highest
risk of developing drug
resistance
Bangkok TDF 2400 IVDU 1204 – TDF 74% 84% efficacy among
2005 1207 - Placebo compliant
 (PrEP)
Pre-exposure Prophylaxis

Iniinom ang gamot araw-araw

upang maiwasan ang HIV
infection sa pamamagitan ng
pakikipagpag-sex nang walang
proteksyon.

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 (PrEP)
Pre-exposure Prophylaxis

Nababawasan ang bisa ng PrEP

kapag pumapalya sa pag-inom ng
gamot.

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 (PrEP)
Pre-exposure Prophylaxis

Kailangan pa ring gumamit ng

condom sa pakikipagtalik kahit
na nagpe PrEP upang
maprotektahan ka sa ibang STIs.
Samakatuwid, kailangan pa ring
mag-condom kung ganito ang
sitwasyon.

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 “On demand PrEP”

Ang pag-inom ng PrEP kung kailan

mo kailangan ay tinatawag na “on-
demand” PrEP.

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 “On demand PrEP”

Ang iskedyul ng “on-demand” PrEP

na nasubukan na ay ang “2-1-1”.

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 “On demand PrEP”

Ito ay ang pag-inom ng 2 pildoras, sa

loob ng 2 hanggang 24 na oras bago
makipag-sex.

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 “On demand PrEP”

Uminom ng 1 pildoras 24 hours

pagkatapos ng first dose, at 1 uling
pildoras 24 hours matapos ang
second dose.

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“On demand PrEP”

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 “On demand PrEP”

May scientific evidence na ang “2-1-

1” schedule ay nagbibigay ng
epektibong proteksyon sa mga gay
at bisexual men sa anal sex nang
walang gamit na condom.

https://www.cdc.gov/hiv/basics/prep/on-demand-prep.html

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 “On demand PrEP”

Hindi pa alam kung ang “on-

demand” PrEP ay mabisang gamitin
ng heterosexual na babae at lalaki,
mga nagtuturok ng droga at
transgender persons.

https://www.cdc.gov/hiv/basics/prep/on-demand-prep.html

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 STUDY POPULATION REGIMEN RESULTS SIDE EFFECTS
IPERGAY 400 MSM 199 Truvada 2* Nausea
201 Placebo 14 Vomiting
S – 2012 Abd Pain
R – 2014 + risk reduction couseling *not using P = 0.013
PrEP but active
Inc crea p=0.042

• a relative reduction of 86% in the incidence of HIV with on

demand PrEP (95%CI: 39.4-98.5%, P=0.002)
Who needs PrEP?
• Juan’s boyfriend, Paolo, is a PLHIV with Undetectable viral load.
• Michael has had “tulo” twice this year.
• Janine is paid more for condomless sex with her clients.
• Karen and Patrick are experimenting with polyamory and swing
with other couples.
• Joshua has regular sex with his partner. They are monogamous and
tested negative for HIV and STDs last month.
• Ben has never had sex yet.
• Robert has scheduled sex 2x a month on his days off, with different
casual partners.
• Philip drinks with his officemates and often ends up fooling around
with the guys when they all get drunk. It’s spontaneous sex so no
one thinks to bring a condom.
 Mahalagang paalala!
Hindi maiiwasan ang pregnancy sa
paggamit ng PrEP!
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PRE EXPOSURE POST
 (PEP)
Post-Exposure Prophylaxis

Ang Post Exposure Prophylaxis o

PEP ay paraan o gamot para
maharang ang HIV pagkatapos ma-
expose sa HIV infection.

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 (PEP)
Post-Exposure Prophylaxis

Ang mga exposure na nabanggit ay

maaring dahil sa…

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 (PEP)
Post-Exposure Prophylaxis

Ang mga exposure na nabanggit ay

maaring dahil sa:
Nalaman mong ang naka-
partner mo ay HIV positive
matapos ang pakikipagtalik.

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 (PEP)
Post-Exposure Prophylaxis

Ang mga exposure na nabanggit ay

maaring dahil sa:

Nakisalo ka sa pagtuturok
gamit ang infected needle.

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 (PEP)
Post-Exposure Prophylaxis

Antiretroviral drug ang ginagamit na

PEP matapos ang isang mapanganib
na exposure upang mapigil ang
pagkahawa sa HIV.

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HOW DOES PEP WORK?
HOW DOES HIV HAPPEN?
 (PEP)
Post-Exposure Prophylaxis

Kailangang uminom agad ng

antiretroviral drugs - mas maaga,
mas mainam- hanggang sa loob ng 72
oras lamang matapos ang exposure
upang ito ay umepekto. Bawat oras
ay mahalaga!

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 Take within 72 hours
 Take for 28 days
Who needs PEP?
• Steff had casual unprotected sex with someone she met
online 48 hours ago
• Keith performed oral sex on a guy he met at a party, who
later disclosed to him was PLHIV
• Vince was having sex with Tim when the condom broke.
Tim was PLHIV with an undetectable Viral load
• Felice tried injecting meth for the first time. She joined a
partee and was served. She did not see the preparation of
her syringe
• Logan had casual unprotected sex 4 days ago. He does not
have any contact details of the person he had sex with