PROPERTIES OF PLASMA

PROTEINS
ALI HAMZA SAAD (ROLL NO. 196)
 • Plasma proteins form colloidal
Type of solutions instead of true
Solution solutions.

Reason • Huge size of plasma proteins

SOLUBILITY

• Albumin = 69,000 dalton

Examples • Globulin = 156,000 dalton
• Fibrinogen = 340,000 dalton
 • Osmotic pressure exerted by the
Definition plasma proteins

• Impermeability through capillary

Reason walls due to huge size

ONCOTIC
PRESSURE Value • 25 mmHg

Major • Albumin
Protein
 • The ratio of weight of a
given volume of a fluid to
Definition the weight of the same
volume of distilled water
measured at 25 ° C
SPECIFIC
GRAVITY OF
PLASMA
PROTEINS • Higher than water
• Lower than blood cells
Value
• Value = 1.026
 • The pH at which a
Isoelectric molecule exists as
pH Zwitterion or dipolar ion.
CONCEPT OF
ISOELECTRIC
pH AND • A hybrid molecule
ZWITTERION Zwitterion containing both positive
(Dipolar and negative charges.
Ion) • Electrically neutral
 Rarely
neutral

CHARGE ON In Strongly • Positively charged

Acidic
PLASMA Solutions
(cations)
PROTEINS
In Strongly • Negatively charged
Alkaline
Solutions
(anions)
 • The ability to resist
Definition change in pH of a
solution

Role of • 1/6 of the total buffering

BUFFER Plasma action of blood
ACTION Proteins

• Having both positive and

Reason negative groups in the
molecule
 Definition • Resistance of blood plasma to flow

• Concentration of plasma proteins

Dependence (especially albumin and fibrinogen)
• Molecular size of plasma proteins
VISCOSITY

Value • 1.3 – 1.7 mPa/s

 • Disorganization of
Definition native protein structure

DENATURATI
ON • Change the physical,
chemical and biological
Effects properties of protein
molecules
 • Increase in viscosity
Physical • Decrease in solubility
• Loss of secondary, tertiary and
Changes quaternary structure

EFFECTS OF
DENATURATIO Chemical • Exposure of chemical groups
• Precipitation of proteins
N ON PLASMA Changes
PROTEINS
Biological • Loss of biological activity
Changes