Metabolic Pathways & Simbiology Models

Acetyl-CoA is a key This step is catalyzed by

starting molecule for the enzyme thiolase.
cholesterol synthesis.

HMG-CoA reductase
This mechanism regulates the
is a key regulatory
production of cholesterol.
enzyme in cholesterol
biosynthesis. It
catalyzes the
reduction of HMG-
CoA to mevalonate
Metabolic Pathways & Simbiology Models

It is a crucial intermediate in
the pathway.

Squalene is
cyclized and
modified through
various
enzymatic
Mevalonate undergoes a reactions to
series of phosphorylation and finally yield
decarboxylation reactions to cholesterol.
produce isopentenyl
pyrophosphate (IPP)
 STATINS

Without Statins Atorvastatin Rosuvastatin

The Statins reduced cholestrol by increasing HMG-CoA

reductase.
Atorvastatin and Rosuvastatin works the same but the are
differences in the side affects.