Rosuvastatin has certain side effects that are not present in Atorvastatin.

Rosuvastatin Atorvastatin

Comparing
Rosuvastatin & o o o Muscle aches
Hematuria Diabetes mellitus
Atorvastatin o
o
Proteinuria
Hypersensitivity
o
o
Nausea
Arthralgia
o Muscle tenderness
o Rhabdomyolysis
o Constipation o Weakness
o Interstitial cystitis
 Comparing Rosuvastatin
& Atorvastatin

Results
Rosuvastatin 10 to 80 mg
Rosuvastatin reduced LDL cholesterol
by 8.2% more than
Atorvastatin Atorvastatin.
Hypercholesterolemia 10mg – 20mg 6 weeks
40mg – 80mg

Meaning that in usage, Rosuvastatin is better.

 Step 2: Step 3:
Rosuvastatin
Reduction of the production of mevalonic acid Low-density lipoprotein receptors
Mechanism
from HMG-CoA. are increased & high sensitivity
CRP levels are decreased.
Step 1:
The statin inhibits HMG-
CoA. Step 3:
Reduce: Increase:
Step 2:
1- TC 1- (HDL-C)
Atorvastatin Prevents HMG-CoA from converting to 2- (LDL-C)
Mechanism mevalonate & the NO. of LDL receptors is 3- (apoB)
increased. 4- (VLDL-
C)
5- (TGs)
Distinctive characteristics

Step 4:

Inflammation at the site.

1- Rosuvastatin does not metabolize 1- Atorvastatin metabolize completely.
completely. 2 -Has a half-life of 14 hours, when active
2- Has a half-life of 19 hours 20 to 30 hours
 Step 2: Step 3:
Rosuvastatin
Reduction of the production of mevalonic acid Low-density lipoprotein receptors
Mechanism
from HMG-CoA. are increased & high sensitivity
CRP levels are decreased.
Step 1:
The statin inhibits HMG-
CoA. Step 3:
Reduce: Increase:
Step 2:
1- TC 1- (HDL-C).
Atorvastati Prevents HMG-CoA from converting to 2- (LDL-C)
n mevalonate & the NO. of LDL receptors is 3- (apoB)
Mechanism increased. 4- (VLDL-C)
5- (TGs)

Distinctive characteristics

Step 4:

Inflammation at the site.

1- Rosuvastatin does not metabolize 1- Atorvastatin metabolize completely.
completely. 2 -Has a half-life of 14 hours, when active
2- Has a half-life of 19 hours 20 to 30 hours