ALBUMIN Most abundant protein DECREASE

Produced in liver Hepatic cirrhosis

A-ACID GLYCOPROTEIN/OROSOMUCOID
LIPOPROTEIN
Syn in liver Burns
Soluble and monomeric Nephrotic syndrome
Responsible for osmotic pressure End-stage renal disease
REVERSIBLE Pregnancy
Elimination half life: 17-18 days
Ex. Salicylates, Phenylbutazone, Penicillin
Primarily basic (cationic) drugs INCREASE
MW: 44,000 Da Myocardial Infarction
Low plasma concentration: 0.4-1% Surgery
Ex. Propranolol, Imipramine, Lidocaine, Lidocaine, Crohn's Disease
Diazepam Trauma
Rheumatoid Arthritis
Macromolecular complexes
According to density and ultracentrifuge
Transport plasma liquids to liver

IA
Binding albumin is saturated
Ex. Diclofenac, Chlorpromazine, Cycloserine
ERYTHROCYTES Total volume: 45%
Endogenous and exogenous
Ex. Pentobarbital, Phenytoin, Flurazepam

GE
GLOBULINS ABY globulins
Certain endogenous
Distilled water and 50% saturated ammonium sulfate
Ex. Corticosteroid, Thyroxin, Vit. B12, Vit. ADEK

METABOLIC PROCESSES IN INFANT

Y
Age Metabolism Capacity Developed
Birth Sulfation
1st week
1st month
aH Reduction and Oxidation
Acetylation
2nd month Glucuronidation
3rd month Glycine Conjugation
Glutathione Conjugation
Cysteine Conjugation
k
GFR MEASUREMENT
GROUP DESCRIPTION CREATININE CLEARANCE
1 Normal function >80 mL/min
be

2 Mild renal impairment 50-80 mL/min

3 Moderate renal impairment 30-50 mL/min
4 Severe renal impairment <30 mL/min
5 End-stage renal disease Dialysis

BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS)

Re

CLASS SOLUBILITY PERMEABILITY

1 High High
2 Low High
3 High Low
4 Low Low
@

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