Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration

name/trade n Frequency/
Dosage
Pantoprazole Proton Pump Treatment of A substituted 40 mg IV OD Increased risk of Nausea, vomiting, - Monitor the patient for
(Pantopraz) Inhibitors erosive esophagitis benzimidazole gastric hypomagnesaemia diarrhoea, any signs of bleeding,
(PPIs), associated with antisecretory agent with diuretics. constipation, such as dark stools or
Antacids gastroesophageal and is also known as Increased risk of flatulence, vomiting blood.
reflux disease and proton pump inhibitor digoxin-induced abdominal pain, - Monitor bowel function.
the treatment of (PPI). It blocks the cardiotoxic effects. dyspepsia, dry - Instruct patient to notify
pathological final step in gastric May increase INR mouth the physician of any side
hypersecretory acid secretion by and prothrombin effects.
conditions specific inhibition of time of warfarin. - Encourage compliance
H+/K+ adenosine May increase with the treatment plan.
triphosphatase plasma
(ATPase) enzyme concentration of
system present on the methotrexate. May
secretory surface of decrease absorption
the gastric parietal of itraconazole,
cell. ketoconazole,
posaconazole,
erlotinib.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage
Human Intravenous Indicated for A normal component 50 mL 1 vial May interact with Severe allergic or - Monitor BP, pulse and
Albumin & Other hypoproteinaemia of the plasma and acts IV Q12H other drugs. anaphylactic respiration, and IV
25% Sterile and hypovolaemia like physiological reactions, albumin flow rate. Adjust
(Plasbumin- Solutions albumin, an essential coagulation flow rate as needed to
25) factor in the abnormality, avoid too rapid a rise in
regulation of plasma electrolyte BP.
volume and tissue imbalance (large - Monitor I&O ratio and
fluid balance. It volume pattern. Report changes in
increases intravascular replacement); urinary output.
oncotic pressure, cardiac, respiratory, - Report chills, nausea,
causing movement of or renal failure; headache, or back pain to
fluids from interstitial increased physician immediately.
into intravascular intracranial
space. It also binds pressure;
and acts as a carrier of hypervolaemia
intermediate
metabolites (including
bilirubin), acidic
drugs, fatty acids,
hormones, enzymes,
trace metals, and dyes.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage
Piperacillin + Antibiotic To treat bacterial Inhibits bacterial 4.5 gms IV Interacts w/ high GI effects (e.g. - Monitor patient for
Tazobactam (penicillins infections in many septum formation and now then doses of heparin, diarrhoea, nausea, diarrhea and initiate
(Tazocure) and beta- different parts of the cell wall synthesis in Q12H oral anticoagulants constipation), rash therapeutic measures as
lactamase body (eg, stomach susceptible bacteria. or other drugs that (maculopapular, needed.
inhibitors) or bowel, lungs, affect blood bullous, urticarial, - If rash develops,
skin, female coagulation or eczemoid), pruritus, monitor patient closely
reproductive thrombocyte fever, headache, and discontinue if lesion
organs) function. Prolongs insomnia progresses.
the neuromuscular - Monitor hematologic
blockade of and coagulation
vecuronium and parameters.
non-depolarising - Monitor sodium intake
muscle relaxants. and electrolyte levels.
Prolongs half-lives
w/ probenecid.
Increased risk of
methotrexate
toxicity.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage
Dibencozide Appetite Used in the Dibencozide increases 3 mg cap 1 Chloramphenicol No major adverse - Advise patient to avoid
(Heraclene Enhancers treatment of anemia the protein "efficiency cap OD might decrease new reactions have been products that contain
Forte) (vitamin B12 coefficient" ie, the blood cells. Taking associated to the caffeine. Report evidence
(cyanocobala percentage of "bound chloramphenicol for use of Heraclene of excessive stimulation.
min and nitrogen" for protein a long time might (Dibencozide) - Warn patient that drug
analogues)) build-up in the body decrease the effects Capsules. Minor may lose its effectiveness
compared to "ingested of dibencozide on side effects include over time.
nitrogen" with food new blood cells. nausea, vomiting,
intake. diarrhea, acidity,
headache, stomach
upset and other GI
disorders.
Generic Classification Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade Frequency/
Dosage
Domperi- GIT For the short-term Blocks dopamine 10 mg tab 1 Concomitant Asthenia, - Assess for nausea,
done (GI Regulators, treatment of receptors in the gut tab TID ac administration of somnolence, vomiting, abdominal
Norm) Antiflatulents nausea and and in the part of the meals anticholinergic headache, distention, and bowel
& Anti- vomiting brain linked to drugs with convulsion, sounds before and after
Inflammato- vomiting (the domperidone may extrapyramidal administration.
ries chemoreceptor trigger antagonize the anti- disorder, - Monitor BP (sitting,
(antiemetic zone, located just dyspeptic effect of depression, standing, lying down) and
(anti-sickness) outside the blood domperidone. dizziness, dry pulse before and
and prokinetic brain barrier). This Antacids or mouth, diarrhea. periodically during
drug) results in increased antisecretory agents therapy.
esophageal and gastric lower the oral - Instruct patient to take
peristalsis, such that bioavailability of as directed. Advise patient
food moves more domperidone. to avoid grapefruit juice
quickly through the during therapy.
stomach and into the
intestine.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage
Calcium + Calcium/with A medicine to help Provides bone and 1 tab BID calcium may reduce Hypercalcemia, - Should be taken with
Vitamin D3 + Vitamins maintain optimum joint care because it absorption of hypercalciuria food
Minerals (dietary bone function and has high levels of quinolones, (excess calcium in
(Calciumade) supplement) reduce the risk of elemental calcium tetracyclines, and the urine), vascular
osteoporosis later in carbonate that helps bisphosphonates. and soft tissue
life. strengthen bones, Concomitant intake calcification
Vitamin D3 for better of calcium and foods (deposition of
calcium absorption, rich in oxalic acid or calcium in blood
and minerals phytic acid may vessels and soft
(magnesium, zinc, and decrease calcium tissue) and
manganese) that help absorption. nephrolithiasis
in making joints Concomitant intake (kidney stones).
flexible. of other products bloating,
containing high dose constipation,
vitamin D may flatulence, and
result in excessive nausea.
doses of vitamin D.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage
Sodium Electrolytes Indicated for use in It is important in 2 tabs TID May affect serum Hypernatraemia; - Instruct patient to take
Chloride adults as electrolyte and fluid concentrations of thirst, reduced exactly as prescribed by
(NaCl) replacement of fluid balance, osmotic lithium. salivation and the doctor. Do not take in
and electrolytes pressure control and lachrymation, larger or smaller amounts
water distribution as it fever, tachycardia, or for longer than
restores sodium ions. hypertension, recommended.
It is used as a source headache, - Sodium chloride may be
of electrolytes and dizziness, taken with or without
water for hydration, restlessness, food.
treatment of metabolic irritability and
acidosis, priming weakness.
solution in
haemodialysis and
treatment of
hyperosmolar
diabetes. It is also
used as diluents for
infusion of compatible
drug additives.
Generic Classificatio Indication Mechanism of action Route/ Interaction Adverse Reaction Nursing Consideration
name/trade n Frequency/
Dosage