Professional Documents
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Toxicity
-rashes, GI symptoms, myopathy, arrhythmias,
hypokalemia
- WBC, hematocrit
v
-Fenofibrate
-fibrate of choice (w/ statin)
-avoided: hepatic and renal dysfunction
-cholesterol gallstones
INHIBITORS OF INTESTINAL STEROLS C. Niacin & Resins
- VLDL & LDL (FCH)
-inhibits intestinal absorption of phytosterols & cholesterol -heterozygoys hypercholesterolemia
- LDL
D. Niacin & Statins
Chemistry and Pharmacokinetics -hypercholesterolemia
-conjugated to active glucuronide -FCH
-peak blood levels (12-14 hrs)
-t : 22 hrs E. Statins & Ezetimibe
-80% - excreted in feces -primary hypercholesterolemia
- levels w/ fibrates -homozygous familial hypercholesterolemia
Levels w/ resins (cholestyramine & others)
-Warfarin & Digoxin F. Statins & Fenofibrate
-no significant interaction - LDL & VLDL
Toxicity
-Myositis
CETP INHIBITORS
-Torcetrapib
- VLDL, LDL
- CV events
DRUG COMBINATIONS
1. VLDL (hypercholesterolemia)
-tx w/ resin
4. Lp(a), HDL