Epidemiology

Classically speaking
 Epi = upon (among)
 Demos = people
 Ology = science
 Epidemiology = the science which deals with what
falls upon people…..
 A Modern Definition
 “The study of the distribution and
determinants of health-related states in specified
populations, and the application of this study to
control health problems."
(Last
J)

Search for knowledge Apply in health service

 Objectives of Epidemiology

1. To describe the distribution and magnitude of health

and disease problems in the population.
2. To identify the etiological factors – risk factors in the
population.
3. To provide the data essential to planning,
implementation and evaluation of services for
prevention, control and treatment of disease and to
setting up of priorities for these services.
The ultimate aim of epidemiology is
 to eliminate or reduce health problem or its

consequences
and
 to promote health and well-being of society as a whole.
 Purposes of Epidemiology
1. To investigate nature / extent of health-related
phenomena in the community / identify priorities
2. To study natural history and prognosis of health-
related problems
3. To identify causes and risk factors
4. To recommend / assist in application of / evaluate
best interventions (preventive and therapeutic
measures)
5. To provide foundation for public policy
 Component:

Disease Frequency- Rate and Ratio e.g

Rate- incidence rate, prevalence rate etc
Ratio- sex ratio, doctor-population ratio
Distribution of Disease-
Disease in community find causative factor

Generate hypothesis

Descriptive epidimiology
Determinants of Disease-
To test hypothesis

Analytic epidemiology

Help in
develop sound scientific
program
Terms to know
 Endemic: constant presence of a disease in
a given population
 epidemic: outbreak or occurrence of one
specific disease from a single source, in a
group population, community, or
geographical area, in excess of the usual level
of expectancy
 pandemic: epidemic that is widespread
across a country, or large population, possible
worldwide
 Epidemiology versus clinical medicine

Epidemiology Clinical medicine

 Unit of study is a defined

 Unit of study is case
population or population at
risk
 Concerned with sick as well  Concerned with only sick
as healthy
 Investigator goes to the
community
 Patient comes to doctor
 identify source of infection,
 Seeks diagnosis, derives
mode of spread, an Etiological prognosis, prescribes
factor, future trend or specific treatment
recommend control measures
 Epidemiological Approach
Asking questions
 Making comparisons
● Asking questions may provide clues to cause or
aetiology of disease e.g.
Related to health event
 What is the event,
 what is its magnitude,
 where did it happen,
 when did it happen,
 who were affected,
 why did it happen?
MAKING COMPARISONS
 Making comparisons will help draw

inferences to support asking questions.

 This comparison may be:

● Between those with the disease and those

without the disease;
● Those with risk factor and those not
exposed to risk factor;
 RATES
A rate measures the occurrence of some
particular event in a population during a
given period of time.

Death rate = Number of deaths in one year X 100

Mid-year population
Crude rate

Specific rate

Standardized rates
SPECIFIC DEATH RATES
 The specific death rate may be:
 a) cause or disease specific
 B) related to specific groups like age
specific or sex-specific
PROPORTIONAL MORTALITY
RATE
 Proportional Mortality rate from a
specific disease
 Under-5 Proportional Mortality Rate
 Proportional Mortalityfor a person aged
50 years and above
MEASUREMENT OF
MORBIDITY
 INCIDENCE
 PREVALENCE
 Incidence

 Number of new cases of a disease which come

into being during a specified period of time.
(Number of new cases of specific disease during
a given period)/(population at risk during that
period) x 1000

Importance: If incidence increasing, it may

indicate failure or ineffectiveness of control
measure of a disease and need for better/new
health control measure.
 Prevalence
 Number of current case (old and new) of a specified disease
at a point of time
 It help to estimate the burden of disease
 Identify potentially high-risk populations. They are
essentially helpful to plan rehabilitation facilities, manpower
needs, etc.
(Number of current case of a specified disease at a point of
time)/(estimated population at the same point of time) x 1000
 Point prevalence AND Period prevalence
 Relationship between incidence and
prevalence

 Prevalence =Incidence x Duration

Three essential characteristics that are
examined to study the cause(s) for
disease in analytic epidemiology are...

 Host
 Agent
 Environment
 Host Factors

 Behaviors
 Genetic
predisposition
 Immunologic factors

• Influence the chance for disease or its

severity
 Agents

 Biological
 Physical
 Chemical

• Necessary for disease to occur

 Environment

 External conditions

• Contribute to the disease process

Epidemics arise when host, agent, and
environmental factors are not in balance

 Due to new agent

 Due to change in existing agent (infectivity,
pathogenicity, virulence)
 Due to change in number of susceptibles in the
population
 Due to environmental changes that affect
transmission of the agent or growth of the
agent
 EPIDEMIOLOGICAL METHODS

.
The methods they employs can be classified as:
1. Observational studies
a. Descriptive studies
b. Analytical studies
– Case control studies
– Cohort studies
2. Experimental/interventional studies
– Randomized control studies
– Field trials
– Community trials
Descriptive observations pertain to the
“who, what, where and when of health-
related state occurrence”. However,
analytical observations deal more with the
‘how’ of a health-related event occur.

Experimental/interventional studies consist of

Randomized control trial (often used for
new medicine or drug testing), field trial
(conducted on those at a high risk of
geting a disease), and community trial
(research on social originating diseases)
Descriptive Studies
Steps in conducting a descriptive study.
Descriptive studies form the first step in any process
of investigation.
These studies are concerned with observing the
distribution of disease in populations.
1. Defining the population.
2. Defining disease under study.
3. Describing the disease.
4. Measurement of disease
5. Compare
6. Formulate hypothesis-
Defining the population. Defined population
may be the whole population or a
representative sample.
 It can also be specially selected group such

as age and sex groups, occupational groups,

hospital patients, school children, small
community, etc.
2. Defining disease under study.
3. Describing the disease.
Disease is examined by the epidemiologist by
asking three questions:
● When is the disease occurring—time
distribution?
● Where is it occurring—place distribution?
● Who is getting the disease—person distribution?
A. Time Distribution
 Short-term fluctuations
 Periodic fluctuations;
 Long-term or secular trends
Short-term fluctuation

A Common source epidemics

- single exposure/point source epidemic
-Continous or multiple exposure epidemic

B Propagated epidemic
a. Person to person
b. Arthropod vector
c. Animal reservoir

C Slow epidemic
 Periodic fluctuations;
a) Seasonal –measles (early spring)
b) cyclic- occur in cyclic order over a
short period of time which may be
days, weeks, months or years.

 Long-term or secular trends;

B. Place Distribution
 International variations:

Cancer of stomach very common in Japan

less common in US.
oral cancer- India
Breast cancer- Low-japan, high-western
 National variations, e.g. Distribution of fluorosis,
 Rural-urban differences, e.g.
CVD, Mental illness more common in urban areas.
Skin diseases, worm infestations more common in
rural areas.
 Local distributions, e.g. Spot maps- John Snow in
London to incriminate water supply as cause of
cholera transmission in London.
cholera cases in proximity to
water pump, 1854
 C. Person Distribution
Age: e.g.
Measles is common in children,
Cancer in middle age
Degenerative diseases in old age.
Sex:
Women- Lung cancer-less
Hyperthyroidism- more
c. Social class- Diabetes, Hypertenson– upper class
4. Measurement of disease- Mortality/ Morbidity

5. Compare- Between different population, subgroups

6. Formulate hypothesis. On basis of all data

epidemiologist form hypothesis.
 Cross-sectional studies
 Cross-sectional study is also called prevalence study.
 Cross-sectional study is the simplest form of
observational study.
 It is based on single examination of cross-section of
population at one point of time.
 If the sampling methodology is accurate, results can be
projected to the entire population.
 They are more useful for chronic illnesses, e.g.
hypertension.
 Cross-sectional studies save on time and resources, but
provide very little information about natural history of
disease and incidence of illness.
 Case- control studies

 It start from effect and then proceed to cause

 Both exposure and outcome have occurred
before start of the study
 The study proceeds backwards from effect to
cause
 Select subjects based on their disease status.
A group of individuals that are disease positive
(the "case" group) is compared with a group of
disease negative individuals (the "control"
group).
 The control group should ideally come from the
same population that gave rise to the cases.
Basic steps in a case-control study
 1. Selection of cases and controls

 2. Matching

 3. Measurement of exposure

 4. Analysis and interpretation.

 A 2×2 table is constructed, displaying exposed cases
(A), exposed controls (B), unexposed cases (C) and
unexposed controls (D).

CASE CONTROLS
EXPOSED A B
UNEXPOSED C D

 To measure association is the odds ratio (OR), which

is the ratio of the odds of exposure in the cases (A/C)
to the odds of exposure in the controls (B/D), i.e.
OR = (AD/BC).
 Odds ratio
 It is a measure of strength of association between the
risk factor and outcome.
 The derivation of the odds ratio is based on three

assumptions:
● The disease being investigated is relatively rare
● The cases must be representative of those with the disease
● The controls must be representative of those without the
disease.
Odds ratio a.d/b.c
33X27/55X2 = 8.1
 People who smoke 5 cigarettes per day

showed a risk of having lung cancer 8.1

times higher as compared to non-smokers.
 OR is > 1- "those with the disease are more
likely to have been exposed,"
OR close to 1 then the exposure and disease
are not likely associated.
OR <1-exposure is a protective factor in the
causation of the disease.
 Case control studies are usually faster and more
cost effective
 Sensitive to bias (selection bias).
 The main challenge is to identify the appropriate
control group;
 The distribution of exposure among the control
group should be representative of the distribution
in the population that gave rise to the cases.
Cohort Study

 It look at cause and proceed to effect

 study before the disease is manifest and proceed to
study over a period of time for the disease to occur.
 Cohort means a group of people sharing a common
experience.
 Cohort studies are often prospective studies, they
can be retrospective also, or a combination of both
prospective and retrospective components can be
brought in.
 Steps in a cohort study:
1. Selection of study subjects
2. Obtaining data on exposur
3. Selection of comparison groups
4. Follow-up
5. Analysis.
 CHD Develop CHD does total
not develop
Smoker 84 (a) 2916 (b) 3000 (a+b)

Nno-smoker 87 (C) 4913 (d) 5000 (c+d)

Total 171 (a+c) 7829 (b+d) 8000

The incidence rates of CHD among smokers i.e. a/(a+b)

=84/3000 =28 per 1000

The incidence rates of CHD among non-smokers i.e.

=c/(c+d)
=87/5000 =17.4 per 1000
 Then, we must determine if the
incidence rate among the smokers is
significantly more than among the non-
smokers by using the chi-square test.
 Relative risk (RR)

 It is ratio of incidence of the disease among the exposed and

incidence among the non-exposed.

RR (incidence of disease among exposed)/

(Incidence of disease among non-exposed)
=a/(ab)/c/(cd)
=28/17.4
=1.6
 If RR is more than 1, then there is a positive association
 If RR is equal to 1, then there is no association
 Smokers develop CHD 1.6 times more than nonsmokers.
 Attributable risk (AR)

 This is defined as amount or proportion of disease incidence

that can be attributed to a specific exposure.
 It indicates to what extent the disease under study can be
attributed to the exposure:
(incidence of disease among exposed)
- (incidence of disease among non exposed)/
(Incidence of disease among exposed)
=28-17.4/28
= 10.6/28 = 0.379 = 37.9%
 37. 9% of CHD among the smokers was due to smoking.
Randomized Control Studies

 Essential elements are:

 Drawing up a strict protocol,
 selecting reference and
 experimental populations,
 randomization,
 intervention,
 follow-up
 assessment of outcome.
 Randomization is a statistical procedure where
participants are allocated into groups called study and
control groups to receive or not to receive an
experimental therapeutic or preventive procedure,
intervention.
Randomization is an attempt to avoid bias and allow
comparability.
Types of randomized control studies are:
Clinical trials, e.g. drug trials
Preventive trials, e.g. trials of vaccines

Risk factor trials, e.g. trials of risk factors of

cardiovascular disease, e.g. tobacco use, physical

activity, diet, etc.
Cessation experiments, e.g. smoking cessation

experiments for studying lung cancer.