IMMUNOLOGI

(MLTHSC1042)
Nilaian Penilaian berterusan Peperiksaan akhir : 2 Jam kredit : 40%(Mid sem & Assigment) : 60%
Oleh:

Wan Norfaisal Amri b. Wan Noridan

(Bsc. (Hons.) Biomedical Science UKM)

Tel: 013-3452970 Lecturer Medical Lab Technology Department Science and Technology Islamic College

INTRO.
1. Definition 2. Importanc e 3. Immunity type 4. Immunity characteris tic)

CELL&ORGAN Cell 1. Agranulocytes

Lymfphocytes Monocytes 1. 2. 3. 4.

HOW
Antigen Antibody Agglutination Non-specific immunologic reaction First barrier Scnd barrier 5. Specific immunologic reaction Third barrier 6. Cytokines

DISEASE
1. Hipersen sitiviti 2. HLA 3. Immunol ogical disorder

TEST
1. Immun oesei 2. Immun openda flour

2. Granulocytes Neutrophile Basophile Eosinophile 3. Dendritic cell 4. Mast cell 5. Others

Organ 1. Limfoid primer Bone marrow Thymus

2.Limfoid sekunder Lymphatic Vessel Lymph Nodes

REFERENCE BOOKS
1. A SHORT COURCE IMMUNOLOGY FIFTH EDITION Author: Richard coico, Geoffrey sunshine, El Benjamin 2. A SHORT COURCE IMMUNOLOGY SECOND EDITION Author: Eli Benjamin and friends 3. Others

PENGENALAN
Objektif pembelajaran:

DEFINISI KEPENTINGAN JENIS CIRI-CIRI

1. Memahami definisi immunologi dari segi bahasa dan istilah 2. Mengetahui kepentingan sistem imun 3. Mengetahui jenis-jenis sistem imun dalam manusia beserta ciri2 umumnya

DEFINISI
Immunologi Immun-pertahanan badan logi- Pengetahuan/Ilmu/ Definisi: Bagaimana sistem badan melindungi badan daripada patogen dan bahan-bahan yang merbahaya

KEPENTINGAN SISTEM IMUN



Melindungi badan daripada bahan-bahan yang merbahaya (virus, bakteria, fungi, patogen, parasit dll) Memusnahkan sel yang tidak normal dalam badan (sel kanser) Mencegah daripada berlakunya pemusnahan sel sendiri (Autoimmune disease)

Kepentingan pada masa akan datang.. Gabungan bidang immunologi, genetik dan bioteknologi menyumbang kpd pemahaman tentang: Jangkitan  Kanser yg melibatka sum-sum tulang dan sel darah  Reaksi allergik  Penyakit autoimmune  Penyakit kekurangan sel2 dlm sistem imun  Penyakit berkaitan dengan immunosuppresion

JENIS
1) INNATE IMMUNITY 2) ACQUIRED IMMUNITY

CIRI-CIRI UMUM
NATURAL IMMUNITY (semulajadi)
1. 2. 3. 4.

Tidak spesifik pada antigen tertentu Respon segera dan cepat (minit) Tiada memori Komponen imuniti:
  

Pertahanan semulajadi (e.g.kulit) Sel Fagosit Bahan larut (protein komplemen)

ACQUIRED IMMUNITY (perolehan) Contoh:

1. 2. 3. 4.

Spesifik terhadap antigen tertentu Respon yang lambat(beberapa hari) Mempunyai memori Komponen immuniti:
 

Chicken pox Vaksinasi rubella

Limfosit Antibody

NATURAL IMMUNITY (semulajadi)

1)

Physical barrier (Perlindungan fizikal) - skin - mucous membrane in respiratory - hairs in the nasal tract - lining cells of the intestinal tract

2) Chemical barrier (perlindungan kimia) - gastric juice - saliva (air liur) - sweat (peluh) - tears - human milk

3) Phagocytosis - phagocyte cells engulf and destroy an invading organism, cellular debris, toxin and foreign body.. *phagocytic cells - Neutrophil and macrophages

4) Action of natural killer cells - non-specific, non-phagocytic cells which can damage virus-infected tissue cells.. 5) Action of bodys natural microbial flora (bacteria normally found in certain part of the body) 6) Influence by genetic factor

ACQUIRED IMMUNITY (perolehan)



Specific immune reaction against a foreign antigen (invading organism, harmful cell or toxic substance) 2 types of reaction

Humoral immune response (humoral) Cell mediated immune response (sellular)

Humoral immune response - Antibody produced by antigen stimulated immune cells

(B-lymphocyte) - Circulate in the blood - Produce antibody to react specifically against the specific antigen

Cell-mediated immune response

Immune cells (T-Lymphocyte and macrophages) directly attack intracellular pathogens, tumor cells and foreign tissue

Acquired Immunity
 

Active Passive

Active acquired immunity

recognized a foreign antigen react specifically destruction inactivate record information about it..

Occurs when:

Naturally when the body exposed to infection Artificially when a person is stimulated to produce antibodies (immunized or vaccinated against a particular disease)

Passive acquired immunity



Antibody that has been formed in another person/animal are introduced into the body of a non-immune person (antibody transfer) Occurs when:

Naturally (from placenta to baby during pregnancy, breast milk) Artificially (receive antitoxin/gammaglobulin in the treatment)

Kesimpulan


Natural (Non-specific)

Acquired (Specific)

Mechanical barrier Chemical barrier Phagocytosis Killer cells Bodys natural microbial flora Genetic factor

Pasive


Transplacental/breast milk Antitoxin/gammaglobulin

Active
 

Infection Immunization/vaccination

end