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  • Alprazolam (Xanax) Basics: Uses, Mechanism of Action, Side Effects

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    Aishiteru Mawarna B La
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    Alprazolam is a benzodiazepine that reduces anxiety, causes sleepiness, and relaxes muscles by enhancing the effects of the inhibitory neurotransmitter GABA. It is used to treat anxiety, insomnia, and seizures. While it provides rapid relief, alprazolam is only approved for short-term use and poses risks of tolerance and dependence if taken long-term or discontinued abruptly. It works by binding to GABA receptors in the central nervous system to slow nerve signals and produce a calming effect.

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    ALPRAZOLAM

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    Alprazolam is a benzodiazepine that reduces anxiety, causes sleepiness, and relaxes muscles by enhancing the effects of the inhibitory neurotransmitter GABA. It is used to treat anxiety, insomnia, and seizures. While it provides rapid relief, alprazolam is only approved for short-term use and poses risks of tolerance and dependence if taken long-term or discontinued abruptly. It works by binding to GABA receptors in the central nervous system to slow nerve signals and produce a calming effect.

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    241 views13 pages

    Alprazolam (Xanax) Basics: Uses, Mechanism of Action, Side Effects

    Uploaded by

    Aishiteru Mawarna B La
    Alprazolam is a benzodiazepine that reduces anxiety, causes sleepiness, and relaxes muscles by enhancing the effects of the inhibitory neurotransmitter GABA. It is used to treat anxiety, insomnia, and seizures. While it provides rapid relief, alprazolam is only approved for short-term use and poses risks of tolerance and dependence if taken long-term or discontinued abruptly. It works by binding to GABA receptors in the central nervous system to slow nerve signals and produce a calming effect.

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    of 13

    ALPRAZOLAM (Xanax)

    Alprazolam

    is

    part

    group

    of

    benzodiazepine 1) Function :Reducing anxiety :Causing sleepiness :Relaxing muscles :Stopping seizures :Impairing short-term memory

    2) Alprazolam can use to for "off-label" purposes such as for 1)agitation, 2)insomnia 3) Premenstrual dysphoric disorder (PMDD)

    It act by enhancing the effects of (GABA) GAMMA AMINOBUTYRIC ACID receptor so it can slown down or stop certain nerve signals in the brain Its are very special because have Antidote for alprazolam is FLUMAZENIL (Romazicon)

    No FDA approve for long term use. They are approved only for the short-term use for several conditions It can develop tolerance and have risk of dependence remember: It cannot stop immediately because it can cause withdrawal symptom

    MECHANISM OF ACTION

    Alprazolam binds to gamma-aminobutyric acid (GABA) receptor within the CNS & enhances the effects of GABA GABA is a brain chemical that is naturally charming It slow down or stop certain nerve signals in the brain Alprazolam is known as mild tranquilizers, sedatives, or central nervous system depressants. Alprazolam may have antidepressant activity too. Therapeutic properties of alprazolam:

    Anxiolytic Anticonvulsant Muscle relaxant Hypnotic Amnesia

    HOW ALPRAZOLAM WORKS?


    Alprazolam is immediately absorbed into body through your stomach & small intestine and GIT with bioavalability 80-100% It delivered to liver and its hydroxylated to ahydroxyalprazolam which pharmacologically active but less than parent compound Within 1 to 2 hours of ingestion, the body reaches its peak plasma concentrations mainly at serum albumin Results of Alprazolam pharmacology tests have shown that with several daily doses of Alprazolam, high anxiety patients reach steadiness within seven days.

    Excreted

    in urine as glucuronides

    WHAT ALPRAZOLAM DOES Acts as body's natural tranquilizer - producing a calming effect on the brain. pharmacology studies shown Alprazolam is effective as anti-depressant (controls panic disorders and anxiety attacks) Works mostly in the brain to: reduce emotional reactions tension and fear improving thinking memory muscle tone control of consciousness overall coordination within the human nervous system

    Alcohol
    Barbiturates

    e.g : amobarbital(Amytal) Certain antifungals or antibiotics e.g : Itraconazole (Sporanox) Narcotics e.g : morphine Grapefruit juices Oral contraceptives (birth control pills) Benzodiazepines e.g : Diazepam (Valium) Protease inhibitor e.g : Indinavir (Crixivan) Seizure medication

    FDA

    pregnancy category D, Aplrazolam can cause birth defects in an unborn baby. - Do not use aplrazolam without your doctors consent if you are pregnant - Aplrazolam can pass into breast milk and may harm a nursing baby - Sedative effect of this medication may last longer in older adults. - Accidental falls are common in elderly patients who take benzodiazepines - Use caution to avoid falling or accidental injury while you are taking aplrazolam.

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