Several bundles become fascicle o Connected be CT perimysium Functions of muscle o Movement o Posture o Generates heat
I vs H vs M bands I Z an Asshole
Myosin in thin and thick filament Myosin o 2 heads and a tail o F actin strands twirled on each other o Trpopomyosin holds them together Actin, tropomyosin and troponin
sarcolema - invaginations toward center of the muscle space inside the tubule - T tubule - transverse - junction of the A and I band Pouches on each side of the cytoplasmic reticulum terminal cisterns o Junction of A and I band Triad o One cistern, t tubule, sarcolemma T system T tubule goes to deep part of muscle EM of triad Dystrophin o Glycoprotein complex o Provides strength by providing scaffolding for fibrils o Clinical manif: muscle weakness o X-linked o Destruction of muscles o Dystrophinopathy o Beckers???
Dystophin-glycoprotein complex Protein that anchors triad to basal lamina Provides stiffness to muscles
Motor unit Motor neuron and all muscles it innervates Low innervation vs High innervation High innervation faster movements Low innervation slow, sustained movements
Depends on function of muscle
Neuromuscular junction Bet nerve and muscle Prejunction nerve; postjunction muscle Saltatory conduction o Impulse starts at axon hillock o Along nodes of Ranvier Also called endplate Vesicles pinch off from ER SNAP25 snare proteins where botulitin toxin acts VAMP