Predisposing factors:

vascular insufficiency disorders

genitourinary infections
respiratory infections
IV drug use
immunocompromising diseases
history of blood-stream infections
Indwelling prosthetic devices
Open wounds/
fractures
Microorganisms gain entry
by way of blood
Microorganisms lodge into
an area where circulation
slows
Microorganisms grow
Increase pressure
Vascular compromise
of the periosteum
Infection through the bone
cortex and marrow
Cortical devascularization
fever, night sweats,
chills, restlessness,
nausea and malaise
constant bone pain,
swelling, tenderness,
warmth at the infection site,
restricted movement
of the affected part
necrosis
Formation of new bone
Involcrum
Separation of devitalized
bone from living bone Sequestra
Continues to be an
infected island
Difficulty to reach by
blood borne antibiotics
Debridement
Ischemia
drainage from
sinus tracts
Enlarged sequestrum
Sequestrum move
out to the soft tissue
revascularized
Removal by the normal
immune process
Development of sinus tract
Turns to scar tissue
Site for continued
microorganism growth
Remission and
exacerbation
Chronic stage
Excessive vascular
insufficiency
Loss of organ function Amputation
Healing
Systemic signs may
be diminished with
constant bone pain,
Swelling, tenderness,
warmth at the infection site