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Pharmaceutics Exam 1--This Semester!

Pharmaceutics Exam 1--This Semester!

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Pharmaceutics Exam 1
1. The fig on the right presents the ADME time course of a drug in the body. Which curve
describes the drug concentration change at the drug absorption site? Check graph.
2. Which of the following statements are true?
a. Pharmacokinetics is the study of the biochemical and physiological effects of drug
and their mechanisms of action.
b. Pharmacodynamics is the mathematics to elucidate the time course of drug
concentration in the blood.
c. Pharmacokinetics is the quantitative study of ADME after drug administration via
various routes
d. Bioavailability is how much an active drug ingredient is available at the site of
absorption
e. Absolute bioabailability refers to the availability of a drug product as compared to
another product

3. The following states are true except: Two pharmaceutical equivalents have the same\u2026
a. Two pharmaceutical equivalents have the same active ingredient(s)
b. Same dosage form
c. Same route of administration
d. Same release mechanism
e. Same strength or concentration

4. The following factors can cause low bioavailability of an oral drug product except:
a. Insufficient time in GI tract
b. Fast degradation in the GI tract
c. Fast drug absorption in the GI tract
d. Intestinal secretion of drug by transporters
e. First-pass metabolism by liver

5. Which of the following examples is a drug delivery system intended for local delivery?
a. Transdermal delivery of nicotine from a patch
b. Transdermal delivery of nitroglycerin froma patch for chest pain
c. sublingual delivery of nitroglycerin for chest pain

d. Oral delivery of antacid suspension to neutralize excess gastric acid
e. oral delivery of acetaminophen for muscle pain

6. Which of the following routes of administration has hepatic first pass effects
a. peroral drug delivery
b. transdermal drug delivery
c. intravenous injection
d. topical delivery
e. vaginal delivery

7. Which of the following routes is used for local effect only?
a. sublingual route
b. pulmonary route
c. rectal route
d. otic route
e. nasal route
8) According to overtone\u2019s rule:
a. The cell membranes are composed of protein transporters that transport water
molecules
b. The cell membranes are compsod of protein transporters that transport ionic
molecules
c. the cell membranes are composd of lipids which are diffusible by hydrophilic

molecules
d. the more ionic a molecule is, the greater its membrane permeability
e. the more lipophilic a molecule is, the greater its membrane permeability

9. Which of the following transported do not need ATP to provide energy?
a. primary transporters
b. secondary transporters
c.
facilitative transporters
d. solute carrier transporters (SLC)
e. P-glycoproteins
10. The following statements are true except:
a. the polarized cells have two discrete regions of plasma with the same compositions

and functions.
b. the polarized cells on the biological barriers have apical and basolateral domains.
c. polarized cells are found in the intestine & BBB tissues
d. Therapeutic index is the ratio between min toxic concentration and minimum

effective concentration
e. Therapeutic index is the bigger the better

11. The Pglycoprotein is located at
a. both sides of the GI tract epitheliu cell
b. b. the basolateral side of the GI tract epithelium cell
c. c. the basolateral site of the GI tract blood vessel
d. The apical side of the blood vessel epithelium cell at blood brain barrier
e. Both sides of the blood vessel epithelium cell at blood brain barrier

12. The BCRP belongs to the transporter family of
a. ABCA

b. ABCB c. ABCC d. ABCD e. ABCG

13. Which of the following transporters are efflux pumps?
MRPs
14. Which of the following statements is true?
a. concerted transport across polarized cells uses efflux pumps on both apical and
basolateral domains to move drugs out of the cells
b. Concerted transport across polarized cells uses influx pumps on both apical and
basolateral domains to move drugs into the cells
c. Concerted transport across polarized cells uses transporters on both apical and
basolateral domains to move drugs in the same direction

15. The following are steps of concerted transport except:
a. Uptake
b. Export

c. sedimentation
d. phase one metabolism
e. phase two metabolism

16. The following types of metabolism are conducted by CYP450 enzymes except:
a. oxidation
b. hydrolysis
c. introduce NH2 group
d. Introduce OH group

e. Introduce CH3 group
17. The followings are phase II metabolism EXCEPT
a.
reduction
b. acetylation
c. glucuronidation
d. sulfate conjugation
e. glycine conjugation
18. The following substances may inhibit drug metabolism except:
a. Tobacco
b. Grapefruit juice

c. Drugs with a pyridine group
d. Drugs with a quinoline group
e. Drugs with an imidazole group

19. The following statements are true Except
a. the induction of drug metabolism reduces the drug bioavailability
b. the induction of drug metabolism may cause drug-drug interactions
c. the induction of drug metabolism shortens the drug action
d. The induction of drug metabolism leads to drug accumulation

e. the induction of drug metabolism may be caused by food effects

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